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http://hdl.handle.net/1942/22787
Title: | Proteomics applications in Caenorhabditis elegans research | Authors: | Husson, Steven J. Moyson, Sofie VALKENBORG, Dirk Baggerman, Geert Mertens, Inge |
Issue Date: | 2015 | Source: | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 468(4), p. 519-524 | Abstract: | The free-living nematode Caenorhabditis elegans is one of the most studied models in a wide variety of research fields with applications in agro- or pharmaceutical industries. It has been used for the development of new anthelminthic drugs and was proven to yield key insights in neurodegenerative diseases and metabolic syndromes. Due to its suitability for high-throughput genetic screens, efficiency for RNA interference approaches and the availability of thousands of mutants, most studies were carried out at the genetic level. However, determining the cellular function of each gene product remains an unfinished goal in this post-genomic era. A systems biology approach focusing on the actual gene products (i.e. proteins) can help unraveling this puzzle. A fundamental pillar in this research is mass spectrometry-based proteomics. We here provide an in-depth overview of proteomics-related studies in C. elegans research, with special emphasis on the methodologies and biological applications. | Keywords: | caenorhabditis elegans; peptidomics; proteomics; systems biology; biological applications | Document URI: | http://hdl.handle.net/1942/22787 | ISSN: | 0006-291X | e-ISSN: | 1090-2104 | DOI: | 10.1016/j.bbrc.2015.11.026 | ISI #: | 000367868500001 | Rights: | © 2015 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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biochemical.pdf Restricted Access | Published version | 323.53 kB | Adobe PDF | View/Open Request a copy |
WormProteomicsReview_HussonSJ_BBRC_R1 (1).pdf | Peer-reviewed author version | 359.95 kB | Adobe PDF | View/Open |
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