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http://hdl.handle.net/1942/22817
Title: | Image Informatics Strategies for Deciphering Neuronal Network Connectivity | Authors: | Detrez, Jan R. Verstraelen, Peter Gebuis, Titia Verschuuren, Marlies KUIJLAARS, Jacobine Langlois, Xavier Nuydens, Rony Timmermans, Jean-Pierre De Vos, Winnok H. |
Issue Date: | 2016 | Source: | Advances in Anatomy Embryology and Cell Biology, 219, p. 123-148 | Abstract: | Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions. Amongst the neuronal structures that show morphological plasticity are neurites, synapses, dendritic spines and even nuclei. This structural remodelling is directly connected with functional changes such as intercellular communication and the associated calcium bursting behaviour. In vitro cultured neuronal networks are valuable models for studying these morpho-functional changes. Owing to the automation and standardization of both image acquisition and image analysis, it has become possible to extract statistically relevant readouts from such networks. Here, we focus on the current state-of-the-art in image informatics that enables quantitative microscopic interrogation of neuronal networks. We describe the major correlates of neuronal connectivity and present workflows for analysing them. Finally, we provide an outlook on the challenges that remain to be addressed, and discuss how imaging algorithms can be extended beyond in vitro imaging studies. | Document URI: | http://hdl.handle.net/1942/22817 | ISSN: | 0301-5556 | e-ISSN: | 2192-7065 | DOI: | 10.1007/978-3-319-28549-8_5 | ISI #: | 000385738300006 | Rights: | © Springer International Publishing Switzerland 2016 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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