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http://hdl.handle.net/1942/22847
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DC Field | Value | Language |
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dc.contributor.author | STEVENS, An-Sofie | - |
dc.contributor.author | PIROTTE, Nicky | - |
dc.contributor.author | WOUTERS, Annelies | - |
dc.contributor.author | VAN ROTEN, Andromeda | - |
dc.contributor.author | VAN BELLEGHEM, Frank | - |
dc.contributor.author | WILLEMS, Maxime | - |
dc.contributor.author | CUYPERS, Ann | - |
dc.contributor.author | ARTOIS, Tom | - |
dc.contributor.author | SMEETS, Karen | - |
dc.date.accessioned | 2016-12-02T14:50:22Z | - |
dc.date.available | 2016-12-02T14:50:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | CURRENT DRUG TARGETS, 17(12), p. 1414-1437 | - |
dc.identifier.issn | 1389-4501 | - |
dc.identifier.uri | http://hdl.handle.net/1942/22847 | - |
dc.description.abstract | A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells. | - |
dc.description.sponsorship | This work was supported by the Bijzonder OnderzoeksFonds of Hasselt University (BOF08G01) and Hasselt University tUL-impulsfinanciering (project toxicology). The work of An-Sofie Stevens was financed by a PhD grant for An-Sofie Stevens from IWT (Agentschap voor Innovatie door Wetenschap en Technologie) (no. 101442). Maxime Willems was funded by an OZM grant by IWT (no. 100631). | - |
dc.language.iso | en | - |
dc.publisher | BENTHAM SCIENCE PUBL LTD | - |
dc.subject.other | anticarcinogenic therapies; carcinogenesis; redox-related mechanisms; regeneration; stem cells | - |
dc.subject.other | Anticarcinogenic therapies; carcinogenesis; redox-related mechanisms; regeneration; stem cells | - |
dc.title | Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1437 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1414 | - |
dc.identifier.volume | 17 | - |
local.format.pages | 24 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Stevens, An-Sofie; Pirotte, Nicky; Wouters, Annelies; Van Roten, Andromeda; Van Belleghem, Frank; Cuypers, Ann; Artois, Tom; Smeets, Karen] Hasselt Univ, Ctr Environm Sci, Agoralaan,Bldg D, B-3590 Diepenbeek, Belgium. [Van Belleghem, Frank] Open Univ, Fac Management Sci & Technol, Valkenburgweg 177, Heerlen, Netherlands;. [Willems, Maxime] Univ Ghent, Fac Pharmaceut Sci, Lab Pharmaceut Technol, B-9000 Ghent, Belgium. [Willems, Maxime] Univ Ghent, Lab Environm Toxicol & Aquat Ecol, Jozef Plateaustr 22, B-9000 Ghent, Belgium. | - |
local.publisher.place | SHARJAH | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.2174/1389450116666150506112817 | - |
dc.identifier.isi | 000387082600006 | - |
item.fullcitation | STEVENS, An-Sofie; PIROTTE, Nicky; WOUTERS, Annelies; VAN ROTEN, Andromeda; VAN BELLEGHEM, Frank; WILLEMS, Maxime; CUYPERS, Ann; ARTOIS, Tom & SMEETS, Karen (2016) Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth. In: CURRENT DRUG TARGETS, 17(12), p. 1414-1437. | - |
item.contributor | STEVENS, An-Sofie | - |
item.contributor | PIROTTE, Nicky | - |
item.contributor | WOUTERS, Annelies | - |
item.contributor | VAN ROTEN, Andromeda | - |
item.contributor | VAN BELLEGHEM, Frank | - |
item.contributor | WILLEMS, Maxime | - |
item.contributor | CUYPERS, Ann | - |
item.contributor | ARTOIS, Tom | - |
item.contributor | SMEETS, Karen | - |
item.validation | ecoom 2017 | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1389-4501 | - |
crisitem.journal.eissn | 1873-5592 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Redoxrelatedmechanisms.pdf | Peer-reviewed author version | 883.96 kB | Adobe PDF | View/Open |
Stevens(2016).pdf Restricted Access | Published version | 12.52 MB | Adobe PDF | View/Open Request a copy |
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