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Title: | Viral interference of bacterial RNA metabolism machinery | Authors: | Dendooven, Tom Van den Bossche, An Hendrix, Hanne Ceyssens, Pieter-Jan Voet, Marleen Bandyra, KJ De Mayer, Marc Aertsen, Abram NOBEN, Jean-Paul Hardwick Steven Luisi, Ben Lavigne, Rob |
Issue Date: | 2017 | Source: | RNA Biology, 14 (1), p. 6-10 | Abstract: | In a recent publication, we reported a unique interaction between a protein encoded by the giant myovirus phiKZ and the Pseudomonas aeruginosa RNA degradosome. Crystallography, site-directed mutagenesis and interactomics approaches revealed this ‘degradosome interacting protein’ or Dip, to adopt an ‘open-claw’ dimeric structure that presents acidic patches on its outer surface which hijack two conserved RNA binding sites on the scaffold domain of the RNase E component of the RNA degradosome. This interaction prevents substrate RNAs from being bound and degraded by the RNA degradosome during the virus infection cycle. In this commentary, we provide a perspective into the biological role of Dip, its structural analysis and its mysterious evolutionary origin, and we suggest some therapeutic and biotechnological applications of this distinctive viral protein. | Notes: | bfl20@cam.ac.uk; rob.lavigne@kuleuven.be | Keywords: | bacteriophage; phage-host interaction; pseudomonas aeruginosa; RNA degradosome; RNase E | Document URI: | http://hdl.handle.net/1942/23025 | ISSN: | 1547-6286 | e-ISSN: | 1555-8584 | DOI: | 10.1080/15476286.2016.1251003 | ISI #: | 000392612000002 | Rights: | © 2017 Taylor & Francis Group, LLC | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Authors version_Dendooven et al 2016_RNABiology.pdf | Peer-reviewed author version | 319.65 kB | Adobe PDF | View/Open |
Viral interference of the bacterial RNA metabolism machinery.pdf Restricted Access | Published version | 1.18 MB | Adobe PDF | View/Open Request a copy |
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