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http://hdl.handle.net/1942/23115| Title: | Introducing copper-free 'Click' amino acids into the VCAM-1 targeting Nanobody for advanced medical biomaterials | Authors: | HANSEN, Rebekka SMEETS, Sofie ADRIAENSENS, Peter GUEDENS, Wanda |
Issue Date: | 2016 | Source: | Biodetection & Biosensors 2016, Cambridge, UK, 18-19/10/2016 | Abstract: | The goal of this project is to site-specifically functionalize nanobodies with a copper-free ‘click’ functionality, to allow an oriented and covalent coupling to a complementary functionalized surface. A methodology is proposed in which an unnatural amino acid is introduced in the protein structure, with applications towards biosensor chips and affinity-based chromatography. | Keywords: | 'click' chemistry; amber suppression; nanobody | Document URI: | http://hdl.handle.net/1942/23115 | Category: | C2 | Type: | Conference Material |
| Appears in Collections: | Research publications |
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