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http://hdl.handle.net/1942/23132
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DC Field | Value | Language |
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dc.contributor.author | WOUTERS, Kristiaan | - |
dc.contributor.author | Gaens, Katrien | - |
dc.contributor.author | Bijnen, Mitchell | - |
dc.contributor.author | VERBOVEN, Kenneth | - |
dc.contributor.author | Jocken, Johan | - |
dc.contributor.author | WETZELS, Suzan | - |
dc.contributor.author | Wijnands, Erwin | - |
dc.contributor.author | HANSEN, Dominique | - |
dc.contributor.author | van Greevenbroek, Marleen | - |
dc.contributor.author | DUIJVESTIJN, Adriaan | - |
dc.contributor.author | Biessen, Erik | - |
dc.contributor.author | Blaak, Ellen | - |
dc.contributor.author | Stehouwer, Coen | - |
dc.contributor.author | Schalkwijk, Casper | - |
dc.date.accessioned | 2017-02-20T07:39:48Z | - |
dc.date.available | 2017-02-20T07:39:48Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Scientific Reports, 7 (Art N° 42665) | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/1942/23132 | - |
dc.description.abstract | Immune cell accumulation in adipose tissue (AT) is associated with the development of AT inflammation, resulting in metabolic dysfunction. Circulating immune cell patterns may reflect immune cell accumulation in expanding AT. However, data linking human leukocytes in blood and AT is lacking. We investigated whether blood immune cell populations are associated with their counterparts in subcutaneous (scAT) or visceral AT (vAT). Flow cytometry was performed on blood, scAT and vAT from 16 lean and 29 obese men. Circulating natural killer (NK)-cells, classical monocytes and nonclassical monocytes were higher in obese individuals. vAT, but not scAT, of obese individuals contained more inflammatory CD11c+ “M1” macrophages and NK cells compared to lean individuals. Blood classical monocytes were associated with CD11c+ macrophages in vAT but not scAT. This association was unrelated to expression of the adhesion molecules CD11b and CD11c or of the chemokine receptor CX3CR1 on these monocytes. Other AT immune cells were not associated with their respective counterparts in blood. Finally, CD11c+ macrophages and CD4+ T-cells in vAT were associated with their counterparts in scAT. In conclusion, blood classical monocytes reflect CD11c+ macrophages in vAT. | - |
dc.description.sponsorship | Maria Vroomen and José van de Gaar are greatly acknowledged for their technical support. This study was financed by The Netherlands Organization for Scientific Research (NWO) (Veni 916.12.056), The Netherlands Heart Foundation (2013T143) and a Seventh Framework Program (FP7) Grant (CIG 322070) to K.W. | - |
dc.language.iso | en | - |
dc.rights | © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.other | chronic inflammation; obesity; translational research | - |
dc.title | Circulating classical monocytes are associated with CD11c+ macrophages in human visceral adipose tissue | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 7 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Wouters, K (reprint author), Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands. kristiaan.wouters@maastrichtuniversity.nl | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 42665 | - |
dc.identifier.doi | 10.1038/srep42665 | - |
dc.identifier.isi | 000394253000001 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | WOUTERS, Kristiaan; Gaens, Katrien; Bijnen, Mitchell; VERBOVEN, Kenneth; Jocken, Johan; WETZELS, Suzan; Wijnands, Erwin; HANSEN, Dominique; van Greevenbroek, Marleen; DUIJVESTIJN, Adriaan; Biessen, Erik; Blaak, Ellen; Stehouwer, Coen & Schalkwijk, Casper (2017) Circulating classical monocytes are associated with CD11c+ macrophages in human visceral adipose tissue. In: Scientific Reports, 7 (Art N° 42665). | - |
item.validation | ecoom 2018 | - |
item.contributor | WOUTERS, Kristiaan | - |
item.contributor | Gaens, Katrien | - |
item.contributor | Bijnen, Mitchell | - |
item.contributor | VERBOVEN, Kenneth | - |
item.contributor | Jocken, Johan | - |
item.contributor | WETZELS, Suzan | - |
item.contributor | Wijnands, Erwin | - |
item.contributor | HANSEN, Dominique | - |
item.contributor | van Greevenbroek, Marleen | - |
item.contributor | DUIJVESTIJN, Adriaan | - |
item.contributor | Biessen, Erik | - |
item.contributor | Blaak, Ellen | - |
item.contributor | Stehouwer, Coen | - |
item.contributor | Schalkwijk, Casper | - |
crisitem.journal.issn | 2045-2322 | - |
crisitem.journal.eissn | 2045-2322 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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srep42665.pdf | Published version | 609.92 kB | Adobe PDF | View/Open |
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