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http://hdl.handle.net/1942/23236
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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2017-02-28T08:37:46Z | - |
dc.date.available | 2017-02-28T08:37:46Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | JOURNAL OF CARDIAC FAILURE, 22(12), p. 970-977 | - |
dc.identifier.issn | 1071-9164 | - |
dc.identifier.uri | http://hdl.handle.net/1942/23236 | - |
dc.description.abstract | Background: Cardiac resynchronization therapy (CRT) improves morbidity and mortality in heart failure with reduced ejection fraction (HFrEF) and electrical dyssynchrony. CRT patients in clinical practice are older compared with clinical trials. Objective: To investigate clinical response, reverse remodeling, outcome, and mode of death in octogenarians receiving CRT. Methods: Baseline characteristics, change in New York Heart Association (NYHA) functional class, reverse ventricular remodeling, heart failure readmissions, all-cause mortality, and mode of death were evaluated in CRT patients with comparison between octogenarians and nonoctogenarians. In addition, annual mortality rates of octogenarians undergoing CRT were compared with age-matched control subjects from the general population with the use of national actuarial tables. Results: A total of 686 patients, including 178 octogenarians (26%), were followed for 38 +/- 22 months. Octogenarians exhibited a similar change in NYHA functional class (P = .640), left ventricular ejection fraction increase (P = .796), and decrease in end-diastolic (P = .441) and end-systolic (P = .312) diameter compared with their younger counterparts undergoing CRT. Octogenarians had a higher all-cause mortality risk (P < .001), but heart failure readmission risk did not differ (hazard ratio 0.916, 95% confidence interval 0.638-1.313; P = .632). A higher proportion of noncardiac deaths was observed in octogenarians (74%) versus younger patients (50%; P = .022), with worsening heart failure rather than malignant tachyarrhythmia being the main cardiac cause of death. Compared with an age-matched sample from the general population, octogenarians receiving CRT had an equivalent annual mortality rate (log-rank test: P = .444). Conclusions: Octogenarians retain the ability to mount a significant symptomatic and ventricular remodeling response after CRT, resulting in survival similar to the general age-matched population. | - |
dc.description.sponsorship | Pieter Martens, Petra Nijst, and Wilfried Mullens are researchers for the Limburg Clinical Research Program UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk, Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS | - |
dc.rights | © 2016 Elsevier Inc. All rights reserved | - |
dc.subject.other | Elderly; CRT; reverse remodeling; heart failure readmission | - |
dc.subject.other | Elderly; CRT; reverse remodeling; heart failure readmission | - |
dc.title | Mode of Death in Octogenarians Treated With Cardiac Resynchronization Therapy | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 977 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 970 | - |
dc.identifier.volume | 22 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Martens, Pieter; Verbrugge, Frederik H.; Nijst, Petra; Dupont, Mdmatthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Martens, Pieter; Nijst, Petra] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Mullens, Wilfried] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Diepenbeek, Belgium. | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.cardfail.2016.09.023 | - |
dc.identifier.isi | 000389565400005 | - |
item.validation | ecoom 2018 | - |
item.accessRights | Open Access | - |
item.fullcitation | MARTENS, Pieter; VERBRUGGE, Frederik; NIJST, Petra; DUPONT, Matthias & MULLENS, Wilfried (2016) Mode of Death in Octogenarians Treated With Cardiac Resynchronization Therapy. In: JOURNAL OF CARDIAC FAILURE, 22(12), p. 970-977. | - |
item.fulltext | With Fulltext | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | NIJST, Petra | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
crisitem.journal.issn | 1071-9164 | - |
crisitem.journal.eissn | 1532-8414 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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martens 1.pdf Restricted Access | Published version | 748.43 kB | Adobe PDF | View/Open Request a copy |
Mode of death in octogenarians_FINAL_REVISION_JCF_ACCEPT-VERSION edits.pdf | Peer-reviewed author version | 737.35 kB | Adobe PDF | View/Open |
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