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http://hdl.handle.net/1942/23270
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DC Field | Value | Language |
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dc.contributor.author | FRAUSSEN, Judith | - |
dc.contributor.author | CLAES, Nele | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | VAN HORSSEN, Jack | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | Hupperts, Raymond | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.date.accessioned | 2017-03-02T08:56:47Z | - |
dc.date.available | 2017-03-02T08:56:47Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | CLINICAL IMMUNOLOGY, 173, p. 124-132 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.uri | http://hdl.handle.net/1942/23270 | - |
dc.description.abstract | Antibody-independent B cell functions play an important role in multiple sclerosis (MS) pathogenesis. In this study, B cell antigen presentation and costimulation in MS were studied. Peripheral blood B cells of MS patients showed increased expression of costimulatory CD86 and CD80 molecules compared with healthy controls (HC). In MS cerebrospinal fluid (CSF), 12-fold and 2-fold increases in CD86(+) and CD80 B cells, respectively, were evidenced compared with peripheral blood. Further, B cells from MS patients induced proinflammatory T cells in response to myelin basic protein (MBP). Immunomodulatory treatment restored B cell costimulatory molecule expression and caused significantly reduced B cell induced T cell responses. Together, these results demonstrate the potential of B cells from MS patients to induce autoreactive proinflammatory T cell responses. Immunomodulatory therapy abrogated this effect, emphasizing the importance of B cell antigen presentation and costimulation in MS pathology. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | This work was supported by Hasselt University and the Belgian Charcot Foundation. J. Fraussen is a postdoctoral fellow of the Fund for Scientific Research (FWO), Flanders. | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.rights | © 2016 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Multiple sclerosis; B cells; Antigen presentation; Costimulatory molecules; T cells | - |
dc.subject.other | multiple sclerosis; B cells; antigen presentation; costimulatory molecules; T cells | - |
dc.title | B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 132 | - |
dc.identifier.spage | 124 | - |
dc.identifier.volume | 173 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Fraussen, Judith; Claes, Nele; Van Wijmeersch, Bart; van Horssen, Jack; Stinissen, Piet; Somers, Veerle] Univ Limburg, Hasselt Univ, Sch Life Sci, Biomed Res Inst & Transnat, Diepenbeek, Belgium. [Van Wijmeersch, Bart] Revalidat & MS Ctr, Overpelt, Belgium. [van Horssen, Jack] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands. [Hupperts, Raymond] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Neurosci, Maastricht, Netherlands. [Hupperts, Raymond] Acad MS Ctr Limburg, Zuyderland Med Centrum, Sittard, Netherlands. | - |
local.publisher.place | SAN DIEGO | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.clim.2016.10.001 | - |
dc.identifier.isi | 000389864200017 | - |
item.validation | ecoom 2018 | - |
item.contributor | FRAUSSEN, Judith | - |
item.contributor | CLAES, Nele | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | VAN HORSSEN, Jack | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | Hupperts, Raymond | - |
item.contributor | SOMERS, Veerle | - |
item.accessRights | Open Access | - |
item.fullcitation | FRAUSSEN, Judith; CLAES, Nele; VAN WIJMEERSCH, Bart; VAN HORSSEN, Jack; STINISSEN, Piet; Hupperts, Raymond & SOMERS, Veerle (2016) B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses. In: CLINICAL IMMUNOLOGY, 173, p. 124-132. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1521-6616 | - |
crisitem.journal.eissn | 1521-7035 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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faussen 1.pdf Restricted Access | Published version | 1.15 MB | Adobe PDF | View/Open Request a copy |
Fraussen J et al Clin Immunol author version.pdf | Peer-reviewed author version | 629.57 kB | Adobe PDF | View/Open |
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