Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/23273
Title: | The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk | Authors: | HOGERVORST, Janneke van den Brandt, Piet A. Godschalk, Roger W. L. VAN SCHOOTEN, Frederik-Jan Schouten, Leo J. |
Issue Date: | 2016 | Publisher: | NATURE PUBLISHING GROUP | Source: | SCIENTIFIC REPORTS, 6 (Art N° 34902) | Abstract: | It is unclear whether the association between dietary acrylamide intake and endometrial cancer risk as observed in some epidemiological studies reflects a causal relationship. We aimed at clarifying the causality by analyzing acrylamide-gene interactions for endometrial cancer risk. The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline, a random subcohort of 2589 women was selected for a case cohort analysis approach. Acrylamide intake of subcohort members and endometrial cancer cases (n = 315) was assessed with a food frequency questionnaire. Single nucleotide polymorphisms (SNPs) in genes in acrylamide metabolism, sex steroid systems, oxidative stress and DNA repair were assessed through a MassARRAY iPLEX Platform. Interaction between acrylamide and SNPs was assessed with Cox proportional hazards analysis, based on 11.3 years of follow-up. Among the results for 57 SNPs and 2 gene deletions, there were no statistically significant interactions after adjustment for multiple testing. However, there were nominally statistically significant interactions for SNPs in acrylamide-metabolizing enzymes: CYP2E1 (rs915906 and rs2480258) and the deletions of GSTM1 and GSTT1. Although in need of confirmation, the interactions between acrylamide intake and CYP2E1 SNPs contribute to the evidence for a causal relationship between acrylamide and endometrial cancer risk. | Notes: | [Hogervorst, Janneke G. F.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Hogervorst, Janneke G. F.; van den Brandt, Piet A.; Schouten, Leo J.] Maastricht Univ, Sch Oncol & Dev Biol GROW, Dept Epidemiol, Maastricht, Netherlands. [Godschalk, Roger W. L.; van Schooten, Frederik-Jan] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Pharmacol & Toxicol, Maastricht, Netherlands. | Document URI: | http://hdl.handle.net/1942/23273 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/srep34902 | ISI #: | 000392009200001 | Rights: | © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hogervorst 1.pdf | Published version | 368.37 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
17
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
24
checked on Jul 11, 2024
Page view(s)
74
checked on Sep 7, 2022
Download(s)
120
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.