Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23276
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dc.contributor.authorHouben-Wilkes, Sarah-
dc.contributor.authorJoerres, Rudolf A.-
dc.contributor.authorBals, Robert-
dc.contributor.authorFranssen, Frits M. E.-
dc.contributor.authorGlaeser, Sven-
dc.contributor.authorHolle, Rolf-
dc.contributor.authorKarch, Annika-
dc.contributor.authorKoch, Armin-
dc.contributor.authorMagnussen, Helgo-
dc.contributor.authorObst, Anne-
dc.contributor.authorSchulz, Holger-
dc.contributor.authorSPRUIT, Martijn A.-
dc.contributor.authorWacker, Margarethe E.-
dc.contributor.authorWelte, Tobias-
dc.contributor.authorWouters, Emiel F. M.-
dc.contributor.authorVogelmeier, Claus-
dc.contributor.authorWatz, Henrik-
dc.date.accessioned2017-03-02T10:12:26Z-
dc.date.available2017-03-02T10:12:26Z-
dc.date.issued2017-
dc.identifier.citationAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195(2), p. 189-197-
dc.identifier.issn1073-449X-
dc.identifier.urihttp://hdl.handle.net/1942/23276-
dc.description.abstractRationale: Knowledge about the prevalence of objectively assessed peripheral artery disease (PAD) and its clinical relevance in patients with chronic obstructive pulmonary disease (COPD) is scarce. Objectives: We aimed to: (1) assess the prevalence of PAD in COPD compared with distinct control groups; and (2) study the association between PAD and functional capacity as well as health status. Methods: The ankle-brachial index was used to diagnose PAD (ankle-brachial index <= 0.9). The 6-minute-walk distance, health status (St. George's Respiratory Questionnaire), COPD Assessment Test, and EuroQol-5-Dimensions were assessed in patients enrolled in the German COPD and Systemic Consequences-Comorbidities Network cohort study. Control groups were derived from the Study of Health in Pomerania. Measurements and Main Results: A total of 2,088 patients with COPD (61.1% male; mean [SD] age, 65.3 [8.2] years, GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV: 9.4, 42.5, 37.5, and 10.5%, respectively) were included, of which 184 patients (8.8%; GOLD stage I-IV: 5.1, 7.4, 11.1, and 9.5%, respectively, vs. 5.9% in patients with GOLD stage 0 in the COPD and Systemic Consequences-Comorbidities Network) had PAD. In the Study of Health in Pomerania, PAD ranged from 1.8 to 4.2%. Patients with COPD with PAD had a significantly shorter 6-minute-walk distance (356 [108] vs. 422 [103] m, P < 0.001) and worse health status (St. George's Respiratory Questionnaire: 49.7 [20.1] vs. 42.7 [20.0] points, P < 0.001; COPD Assessment Test: 19.6 [7.4] vs. 17.9 [7.4] points, P = 0.004; EuroQol-5-Dimensions visual analog scale: 51.2 [19.0] vs. 57.2 [19.6], P < 0.001). Differences remained significant after correction for several confounders. Conclusions: In a large cohort of patients with COPD, 8.8% were diagnosed with PAD, which is higher than the prevalence in control subjects without COPD. PAD was associated with a clinically relevant reduction in functional capacity and health status.-
dc.description.sponsorshipSupported by Competence Network Asthma/COPD funds to the COPD and Systemic Consequences Comorbidities Network, funded by the German Federal Ministry of Education and Research (BMBF; FKZ 01GI0881). Study of Health in Pomerania is part of the Community Medicine Research network of the University of Greifswald. This study is also a part of the Greifswald Approach to Individualized Medicine research project and is supported by German Federal Ministry of Education and Research grants 01ZZ0403, 01ZZ0103, and 01GI0883; Ministry of Social Affairs and Health of Mecklenburg-Western Pomerania; and the Ministry of Education, Science, and Culture of Mecklenburg Western Pomerania grant 03IS2061A; as well as Lung Foundation Netherlands grant 3.4.10.015 (S.H.-W.) and GlaxoSmithKline grant SCO115406 (S.H.-W.).-
dc.language.isoen-
dc.publisherAMER THORACIC SOC-
dc.subject.otherchronic obstructive pulmonary disease; comorbidities; peripheral vascular disease; health status; functional capacity-
dc.subject.otherchronic obstructive pulmonary disease; comorbidities; peripheral vascular disease; health status; functional capacity-
dc.titlePeripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study-
dc.typeJournal Contribution-
dc.identifier.epage197-
dc.identifier.issue2-
dc.identifier.spage189-
dc.identifier.volume195-
local.format.pages9-
local.bibliographicCitation.jcatA1-
dc.description.notes[Houben-Wilkes, Sarah; Franssen, Frits M. E.; Spruit, Martijn A.] CIRO, Dept Res & Educ, Hornerheide 1, NL-6085 NM Horn, Netherlands. [Joerres, Rudolf A.] Ludwig Maximilians Univ Munchen, Inst Outpatient Clin Occupat Social & Environm Me, Munich, Germany. [Bals, Robert] Saarland Univ Hosp, Dept Internal Med Pulmonol Allergol Resp Intens C, Homburg, Germany. [Franssen, Frits M. E.; Wouters, Emiel F. M.] Maastricht Univ, Med Ctr, Dept Resp Med, Maastricht, Netherlands. [Glaeser, Sven] Univ Med Greifswald, Dept Internal Med Cardiol Intens Care Pulm Med &, Greifswald, Germany. [Holle, Rolf] German Res Ctr Environm Hlth, Comprehens Pneumol Ctr Munich, German Ctr Lung Res,Helmholtz Zentrum Munchen Gmb, Inst Hlth Econ & Hlth Care Management, Neuherberg, Germany. [Schulz, Holger] German Res Ctr Environm Hlth, Comprehens Pneumol Ctr Munich, German Ctr Lung Res,Helmholtz Zentrum Munchen Gmb, Inst Epidemiol 1, Neuherberg, Germany. [Karch, Annika; Koch, Armin] Hannover Med Sch, German Ctr Lung Res, Inst Biostat, Hannover, Germany. [Welte, Tobias] Hannover Med Sch, German Ctr Lung Res, Clin Pneumol, Hannover, Germany. [Magnussen, Helgo] German Ctr Lung Res, Airway Res Ctr North, Lung Clin Grosshansdorf, Pulm Res Inst, Grosshansdorf, Germany. [Spruit, Martijn A.] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Rehabil Res Ctr, Diepenbeek, Belgium. [Vogelmeier, Claus] Philipps Univ, German Ctr Lung Res, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.-
local.publisher.placeNEW YORK-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.classdsPublValOverrule/author_version_not_expected-
dc.identifier.doi10.1164/rccm.201602-0354OC-
dc.identifier.isi000391907300011-
item.accessRightsOpen Access-
item.contributorHouben-Wilkes, Sarah-
item.contributorJoerres, Rudolf A.-
item.contributorBals, Robert-
item.contributorFranssen, Frits M. E.-
item.contributorGlaeser, Sven-
item.contributorHolle, Rolf-
item.contributorKarch, Annika-
item.contributorKoch, Armin-
item.contributorMagnussen, Helgo-
item.contributorObst, Anne-
item.contributorSchulz, Holger-
item.contributorSPRUIT, Martijn A.-
item.contributorWacker, Margarethe E.-
item.contributorWelte, Tobias-
item.contributorWouters, Emiel F. M.-
item.contributorVogelmeier, Claus-
item.contributorWatz, Henrik-
item.fullcitationHouben-Wilkes, Sarah; Joerres, Rudolf A.; Bals, Robert; Franssen, Frits M. E.; Glaeser, Sven; Holle, Rolf; Karch, Annika; Koch, Armin; Magnussen, Helgo; Obst, Anne; Schulz, Holger; SPRUIT, Martijn A.; Wacker, Margarethe E.; Welte, Tobias; Wouters, Emiel F. M.; Vogelmeier, Claus & Watz, Henrik (2017) Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195(2), p. 189-197.-
item.fulltextWith Fulltext-
item.validationecoom 2018-
crisitem.journal.issn1073-449X-
crisitem.journal.eissn1535-4970-
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