Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23308
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dc.contributor.authorde Wit, Nienke-
dc.contributor.authorVANMOL, Jasmine-
dc.contributor.authorKamermans, A.-
dc.contributor.authorHENDRIKS, Jerome-
dc.contributor.authorde Vries, Elga-
dc.date.accessioned2017-03-07T07:48:34Z-
dc.date.available2017-03-07T07:48:34Z-
dc.date.issued2016-
dc.identifier.citationNeurobiology of disease, 107, pag. 57-65-
dc.identifier.issn0969-9961-
dc.identifier.urihttp://hdl.handle.net/1942/23308-
dc.description.abstractThe blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases.-
dc.description.sponsorshipThis work was supported by grants from the ZonMw Memorabel program (NMdW; project nr 733050105) and from the Dutch MS Research Foundation (AK; grant MS-09-358d)-
dc.language.isoen-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.rights© 2016 Elsevier Inc. All rights reserved.-
dc.subject.otherLiver X receptor-
dc.subject.otherBlood-brain barrier-
dc.subject.otherNeuroinflammation-
dc.subject.otherNeurodegenerative disease-
dc.subject.otherTight junction-
dc.titleInflammation at the blood-brain barrier: The role of liver X receptors-
dc.typeJournal Contribution-
dc.identifier.epage65-
dc.identifier.spage57-
dc.identifier.volume107-
local.format.pages9-
local.bibliographicCitation.jcatA1-
dc.description.notesde Wit, NM (reprint author), Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Neurosci Campus Amsterdam, POB 7057, NL-1007 MB Amsterdam, Netherlands. n.dewit1@vumc.nl-
local.publisher.place525 B ST, STE 1900, SAN DIEGO, CA 92101-4495-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.identifier.doi10.1016/j.nbd.2016.09.015-
dc.identifier.isi000411169900006-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.contributorde Wit, Nienke-
item.contributorVANMOL, Jasmine-
item.contributorKamermans, A.-
item.contributorHENDRIKS, Jerome-
item.contributorde Vries, Elga-
item.fullcitationde Wit, Nienke; VANMOL, Jasmine; Kamermans, A.; HENDRIKS, Jerome & de Vries, Elga (2016) Inflammation at the blood-brain barrier: The role of liver X receptors. In: Neurobiology of disease, 107, pag. 57-65.-
item.accessRightsOpen Access-
item.validationecoom 2018-
crisitem.journal.issn0969-9961-
crisitem.journal.eissn1095-953X-
Appears in Collections:Research publications
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