Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/23655
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | BERTRAND, Philippe | - |
dc.contributor.author | WILLEMS, Endry | - |
dc.contributor.author | GIELEN, Ellen | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Giri, S. | - |
dc.contributor.author | Tang, W.H. | - |
dc.contributor.author | Raman, S.V. | - |
dc.contributor.author | Verhaert, D. | - |
dc.date.accessioned | 2017-05-15T08:07:40Z | - |
dc.date.available | 2017-05-15T08:07:40Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | European Heart Journal-Cardiovascular Imaging, 18 (7), p. 787-794 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | http://hdl.handle.net/1942/23655 | - |
dc.description.abstract | To use cardiac magnetic resonance (CMR) imaging with quantitative T2 mapping as surrogate for myocardial water content in patients with advanced decompensated heart failure (ADHF), compare these values with T2-values observed in chronic heart failure, and evaluate the change with decongestive therapy. METHODS AND RESULTS: Volumetric CMR measurements and quantitative T2 mapping were performed in 18 consecutive ADHF patients with clinical signs of volume overload. Eleven patients with stable heart failure were used as controls. Vasodilator therapy and diuretics were administered to achieve a pulmonary arterial wedge pressure (PAWP) of <18 mmHg and central venous pressure (CVP) of <12 mmHg, after which CMR was repeated. ADHF patients (62 ± 12 years; 89% male; left ventricular ejection fraction 23 ± 8%) presented with low cardiac index (2.08 ± 0.59 L/min/m2), high PAWP (25 ± 7 mmHg), and high CVP (14 ± 5 mmHg). After decongestion, the patients had a significant increase in cardiac index (+0.41 ± 0.53 L/min/m2; P = 0.005) and decreases in both PAWP (-9 ± 6 mmHg; P < 0.001) and CVP (-6 ± 5 mmHg; P < 0.001). At baseline, global left ventricular T2-values were higher in ADHF patients compared with controls (59.5 ± 4.6 vs. 54.7 ± 2.2 ms, respectively; P = 0.001). After decongestion, T2-values fell significantly to 55.9 ± 5.1 ms (P = 0.001), comparable with controls (P = 0.580). In contrast, psoas muscle T2-values were similar at baseline (38.6 ± 4.4 ms) vs. after decongestion (37.8 ± 4.8 ms; P = 0.397). Each 1 ms decrease in global left ventricular T2-value during decongestion was associated with a 1.14 ± 0.40 mmHg decrease in PAWP (P = 0.013), after correction for age and gender. CONCLUSION: Patients presenting with ADHF and volume overload have increased global left ventricular-but not psoas muscle-T2-values, which decrease with successful decongestion. Relief of myocardial oedema correlates with haemodynamic unloading. | - |
dc.description.sponsorship | F.V. and P.B. are supported by a Ph.D. fellowship of the Research Foundation-Flanders (FWO). F.V., P.B., and W.M. are researchers for the Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. | - |
dc.language.iso | en | - |
dc.rights | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com. | - |
dc.subject.other | magnetic resonance imaging; myocardium; oedema; systolic heart failure | - |
dc.title | Global myocardial oedema in advanced decompensated heart failure | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 794 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 787 | - |
dc.identifier.volume | 18 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Verbrugge, FH (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. frederik.verbrugge@zol.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/ehjci/jew131 | - |
dc.identifier.isi | 000405458600013 | - |
local.uhasselt.international | yes | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | BERTRAND, Philippe | - |
item.contributor | WILLEMS, Endry | - |
item.contributor | GIELEN, Ellen | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Giri, S. | - |
item.contributor | Tang, W.H. | - |
item.contributor | Raman, S.V. | - |
item.contributor | Verhaert, D. | - |
item.validation | ecoom 2018 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | VERBRUGGE, Frederik; BERTRAND, Philippe; WILLEMS, Endry; GIELEN, Ellen; MULLENS, Wilfried; Giri, S.; Tang, W.H.; Raman, S.V. & Verhaert, D. (2016) Global myocardial oedema in advanced decompensated heart failure. In: European Heart Journal-Cardiovascular Imaging, 18 (7), p. 787-794. | - |
crisitem.journal.issn | 2047-2404 | - |
crisitem.journal.eissn | 2047-2412 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
jew131.pdf Restricted Access | Published version | 2.49 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
19
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
45
checked on Oct 13, 2024
Page view(s)
72
checked on Jul 22, 2022
Download(s)
60
checked on Jul 22, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.