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DC Field | Value | Language |
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dc.contributor.author | Binger, Katrina J. | - |
dc.contributor.author | Côrte-Real, Beatriz F. | - |
dc.contributor.author | KLEINEWIETFELD, Markus | - |
dc.date.accessioned | 2017-05-17T10:02:49Z | - |
dc.date.available | 2017-05-17T10:02:49Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Frontiers in Immunology, 8, p. 1-7 (Art N° 311) | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/1942/23698 | - |
dc.description.abstract | Interleukin-17-producing T helper (Th17) cells are critical for the host defense of bacterial and fungal pathogens and also play a major role in driving pathogenic autoimmune responses. Recent studies have indicated that the generation of Th17 cells from naïve CD4+ T cells is coupled with massive cellular metabolic adaptations, necessary to cope with different energy and metabolite requirements associated with switching from a resting to proliferative state. Furthermore, Th17 cells have to secure these metabolic adaptations when facing nutrient-limiting environments, such as at the sites of inflammation. Accumulating data indicates that this metabolic reprogramming is significantly linked to the differentiation of T helper cells and, particularly, that the metabolic changes of Th17 cells and anti-inflammatory Forkhead box P3+ regulatory T cells are tightly and reciprocally regulated. Thus, a better understanding of these processes could offer potential new targets for therapeutic interventions for autoimmune diseases. In this mini-review, we will highlight some of the recent advances and discoveries in the field, with a particular focus on metabolic demands of Th17 cells and their implications for autoimmunity. | - |
dc.description.sponsorship | KJB was supported by a National Health and Medical Research Council of Australia Early Career Fellowship (APP1037633). MK was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (640116), by a SALK-grant from the government of Flanders, Belgium and by an Odysseus-grant of the Research Foundation Flanders, Belgium (FWO). | - |
dc.language.iso | en | - |
dc.rights | Copyright © 2017 Binger, Côrte-Real and Kleinewietfeld. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | glycolysis; oxidative phosphorylation; immunometabolism; interleukin-17-producing T helper cells; regulatory T cells; autoimmune diseases | - |
dc.title | Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 7 | - |
dc.identifier.spage | 1 | - |
dc.identifier.volume | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 311 | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 640116 | - |
dc.identifier.doi | 10.3389/fimmu.2017.00311 | - |
dc.identifier.isi | 000396791600001 | - |
item.validation | ecoom 2018 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Binger, Katrina J.; Côrte-Real, Beatriz F. & KLEINEWIETFELD, Markus (2017) Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity. In: Frontiers in Immunology, 8, p. 1-7 (Art N° 311). | - |
item.accessRights | Open Access | - |
item.contributor | Binger, Katrina J. | - |
item.contributor | Côrte-Real, Beatriz F. | - |
item.contributor | KLEINEWIETFELD, Markus | - |
crisitem.journal.issn | 1664-3224 | - |
crisitem.journal.eissn | 1664-3224 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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fimmu-08-00311.pdf | Published version | 806.57 kB | Adobe PDF | View/Open |
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