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Title: | The effect of active fluctuations on the dynamics of particles, motors and DNA-hairpins | Authors: | VANDEBROEK, Hans VANDERZANDE, Carlo |
Issue Date: | 2017 | Source: | Soft Matter, 13(11), p. 2181-2191 | Abstract: | Inspired by recent experiments on the dynamics of particles and polymers in artificial cytoskeletons and in cells, we introduce a modified Langevin equation for a particle in an environment that is a viscoelastic medium and that is brought out of equilibrium by the action of active fluctuations caused by molecular motors. We show that within such a model, the motion of a free particle crosses over from superdiffusive to subdiffusive as observed for tracer particles in an in vitro cytoskeleton or in a cell. We investigate the dynamics of a particle confined by a harmonic potential as a simple model for the motion of the tethered head of kinesin-1. We find that the probability that the head is close to its binding site on the microtubule can be enhanced by a factor of two due to active forces. Finally, we study the dynamics of a particle in a double well potential as a model for the dynamics of DNA-hairpins. We show that the active forces effectively lower the potential barrier between the two minima and study the impact of this phenomenon on the zipping/unzipping rate. | Notes: | Vanderzande, C (reprint author), Hasselt Univ, Fac Sci, B-3590 Diepenbeek, Belgium. hans.vandebroek@uhasselt.be; carlo.vanderzande@uhasselt.be | Document URI: | http://hdl.handle.net/1942/23715 | ISSN: | 1744-683X | e-ISSN: | 1744-6848 | DOI: | 10.1039/c6sm02568d | ISI #: | 000397955800006 | Rights: | This journal is (c) The Royal Society of Chemistry 2017 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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