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http://hdl.handle.net/1942/23767
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DC Field | Value | Language |
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dc.contributor.author | BERTRAND, Philippe | - |
dc.contributor.author | Schwammenthal, Ehud | - |
dc.contributor.author | Levine, Robert A. | - |
dc.contributor.author | VANDERVOORT, Pieter | - |
dc.date.accessioned | 2017-05-18T14:33:03Z | - |
dc.date.available | 2017-05-18T14:33:03Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | CIRCULATION, 135(3), p. 297-314 | - |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.uri | http://hdl.handle.net/1942/23767 | - |
dc.description.abstract | Secondary mitral valve regurgitation (MR) remains a challenging problem in the diagnostic workup and treatment of patients with heart failure. Although secondary MR is characteristically dynamic in nature and sensitive to changes in ventricular geometry and loading, current therapy is mainly focused on resting conditions. An exercise-induced increase in secondary MR, however, is associated with impaired exercise capacity and increased mortality. In an era where a multitude of percutaneous solutions are emerging for the treatment of patients with heart failure, it becomes important to address the dynamic component of secondary MR during exercise as well. A critical reappraisal of the underlying disease mechanisms, in particular the dynamic component during exercise, is of timely importance. This review summarizes the pathophysiological mechanisms involved in the dynamic deterioration of secondary MR during exercise, its functional and prognostic impact, and the way current treatment options affect the dynamic lesion and exercise hemodynamics in general. | - |
dc.description.sponsorship | This work was funded, in part, by Research Foundation-Flanders grant 11N7214N (P.B.B.), National Institutes of Health grant R01 HL109506 (R.A.L.), and Leducq Foundation grant 07CVD04. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | © 2017 American Heart Association, Inc. | - |
dc.subject.other | exercise capacity; exercise physiology; exercise testing; heart failure; mitral valve regurgitation; mitral valve surgery | - |
dc.subject.other | exercise capacity; exercise physiology; exercise testing; heart failure; mitral valve regurgitation; mitral valve surgery | - |
dc.title | Exercise Dynamics in Secondary Mitral Regurgitation Pathophysiology and Therapeutic Implications | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 314 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 297 | - |
dc.identifier.volume | 135 | - |
local.format.pages | 19 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Bertrand, Philippe B.; Vandervoort, Pieter M.] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Bertrand, Philippe B.; Vandervoort, Pieter M.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Schwammenthal, Ehud] Sheba Med Ctr, Ctr Heart, Tel Hashomer, Israel. [Levine, Robert A.] Harvard Med Sch, Massachusetts Gen Hosp, Cardiac Ultrasound Lab, Boston, MA USA. | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.116.025260 | - |
dc.identifier.isi | 000392291000013 | - |
item.fullcitation | BERTRAND, Philippe; Schwammenthal, Ehud; Levine, Robert A. & VANDERVOORT, Pieter (2017) Exercise Dynamics in Secondary Mitral Regurgitation Pathophysiology and Therapeutic Implications. In: CIRCULATION, 135(3), p. 297-314. | - |
item.validation | ecoom 2018 | - |
item.contributor | BERTRAND, Philippe | - |
item.contributor | Schwammenthal, Ehud | - |
item.contributor | Levine, Robert A. | - |
item.contributor | VANDERVOORT, Pieter | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0009-7322 | - |
crisitem.journal.eissn | 1524-4539 | - |
Appears in Collections: | Research publications |
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excercise.pdf Restricted Access | Published version | 911.18 kB | Adobe PDF | View/Open Request a copy |
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