Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/23936
Title: | Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium | Authors: | Yang, Wen-Yi Zhang, Zhen-Yu Thijs, Lutgarde Cauwenberghs, Nicholas Wei, Fang-Fei Jacobs, Lotte Luttun, Aernout Verhamme, Peter Kuznetsova, Tatiana NAWROT, Tim Staessen, Jan A. |
Issue Date: | 2017 | Publisher: | WILEY-BLACKWELL | Source: | JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(2), p. 1-12 (Art N° e004692) | Abstract: | Background-Experimental studies have demonstrated that lead and cadmium have direct toxic effects on the myocardium, but the few human studies are limited by design, assessment of exposure, and use of heart failure as a late-stage endpoint. Methods and Results-In a prospective population study, we studied the association of left ventricular (LV) function with blood lead (BPb) and 24-hour urinary cadmium (UCd). In 179 participants randomly recruited from a Flemish population (50.3% women; mean age 39.1 years), geometric mean BPb and UCd at enrollment (1985-2000) were 0.20 mu mol/L and 6.1 nmol, respectively. We assessed systolic and diastolic LV function 11.9 years (median) later (2005-2010) by using Doppler imaging of the transmitral blood flow and the mitral annular movement and speckle tracking. In multivariable-adjusted linear regression, LV systolic function decreased with BPb. For a doubling of exposure, estimates were -0.392% for global longitudinal strain (P=0.034), -0.618% and -0.113 s (1) for regional longitudinal strain (P=0.028)and strain rate (P=0.008), and -0.056 s (1) for regional radial strain rate (P=0.050). Regional longitudinal strain rate (-0.066 s (1), P=0.009)and regional radial strain (-2.848%, P=0.015) also decreased with UCd. Models including both exposure indexes did not allow differentiating whether LV dysfunction was predominately related to BPb or UCd. Diastolic LV function was not associated with BPb or UCd (P=0.159). Conclusions-Although effect sizes were small, our results suggest that environmental exposure to lead, cadmium, or both might be a risk factor for systolic LV dysfunction, a condition often proceeding to heart failure. | Notes: | [Yang, Wen-Yi; Zhang, Zhen-Yu; Thijs, Lutgarde; Cauwenberghs, Nicholas; Wei, Fang-Fei; Jacobs, Lotte; Kuznetsova, Tatiana; Staessen, Jan A.] Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Kapucijnenvoer 35, BE-3000 Leuven, Belgium. [Luttun, Aernout; Verhamme, Peter] Univ Leuven, KU Leuven Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, BE-3000 Leuven, Belgium. [Nawrot, Tim S.] Univ Hasselt, Ctr Environm Sci, Hasselt, Belgium. [Staessen, Jan A.] Maastricht Univ, R&D Grp VitaK, Maastricht, Netherlands. | Keywords: | cadmium; heart failure; lead; population science; systolic function;cadmium; heart failure; lead; population science; systolic function | Document URI: | http://hdl.handle.net/1942/23936 | Link to publication/dataset: | http://jaha.ahajournals.org/content/6/2/e004692 | ISSN: | 2047-9980 | e-ISSN: | 2047-9980 | DOI: | 10.1161/JAHA.116.004692 | ISI #: | 000393594700008 | Rights: | (c) 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
yang 1.pdf | Published version | 871.87 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
15
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
40
checked on Jul 11, 2024
Page view(s)
58
checked on Sep 7, 2022
Download(s)
106
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.