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http://hdl.handle.net/1942/23955
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DC Field | Value | Language |
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dc.contributor.author | SMOLDERS, Sophie | - |
dc.contributor.author | SWINNEN, Nina | - |
dc.contributor.author | KESSELS, Sofie | - |
dc.contributor.author | Arnauts, Kaline | - |
dc.contributor.author | SMOLDERS, Silke | - |
dc.contributor.author | Le Bras, Barbara | - |
dc.contributor.author | RIGO, Jean-Michel | - |
dc.contributor.author | Legendre, Pascal | - |
dc.contributor.author | BRONE, Bert | - |
dc.date.accessioned | 2017-07-06T09:21:57Z | - |
dc.date.available | 2017-07-06T09:21:57Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | GLIA (New York, N.Y. : Print), 65(7), p. 1072-1088 | - |
dc.identifier.issn | 0894-1491 | - |
dc.identifier.uri | http://hdl.handle.net/1942/23955 | - |
dc.description.abstract | Microglia, the immune cells of the central nervous system, take part in brain development and homeostasis. They derive from primitive myeloid progenitors that originate in the yolk sac and colonize the brain mainly through intensive migration. During development, microglial migration speed declines which suggests that their interaction with the microenvironment changes. However, the matrix-cell interactions allowing dispersion within the parenchyma are unknown. Therefore, we aimed to better characterize the migration behavior and to assess the role of matrix-integrin interactions during microglial migration in the embryonic brain ex vivo. We focused on microglia-fibronectin interactions mediated through the fibronectin receptor alpha 5 beta 1 integrin because in vitro work indirectly suggested a role for this ligand-receptor pair. Using 2-photon time-lapse microscopy on acute ex vivo embryonic brain slices, we found that migration occurs in a saltatory pattern and is developmentally regulated. Most importantly, there is an age-specific function of the alpha 5 beta 1 integrin during microglial cortex colonization. At embryonic day (E) 13.5, alpha 5 beta 1 facilitates migration while from E15.5, it inhibits migration. These results indicate a developmentally regulated function of alpha 5 beta 1 integrin in microglial migration during colonization of the embryonic brain. | - |
dc.description.sponsorship | Financial support for this research was granted by Impulse financing tUL (transnationale Universiteit Limburg), UHasselt (BOF13N01, BOF16NI04), Research Foundation of Flanders (FWO G0A0513), the Interuniversity Attraction Poles Program – Belgian State – Belgian Science Policy (IAP-P6/31 and P7/10), Agency for Innovation by Science and Technology (IWT O&O JJDDIPS) and Rotary campaign “Hope in Head”. | - |
dc.language.iso | en | - |
dc.rights | (C) 2017 Wiley Periodicals | - |
dc.subject.other | blood vessels; cell adhesion molecules; cell migration inhibition; embryo; fibronectins | - |
dc.title | Age-specific function of alpha 5 beta 1 integrin in microglial migration during early colonization of the developing mouse cortex | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1088 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1072 | - |
dc.identifier.volume | 65 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/glia.23145 | - |
dc.identifier.isi | 000401345400005 | - |
item.contributor | SMOLDERS, Sophie | - |
item.contributor | SWINNEN, Nina | - |
item.contributor | KESSELS, Sofie | - |
item.contributor | Arnauts, Kaline | - |
item.contributor | SMOLDERS, Silke | - |
item.contributor | Le Bras, Barbara | - |
item.contributor | RIGO, Jean-Michel | - |
item.contributor | Legendre, Pascal | - |
item.contributor | BRONE, Bert | - |
item.accessRights | Open Access | - |
item.fullcitation | SMOLDERS, Sophie; SWINNEN, Nina; KESSELS, Sofie; Arnauts, Kaline; SMOLDERS, Silke; Le Bras, Barbara; RIGO, Jean-Michel; Legendre, Pascal & BRONE, Bert (2017) Age-specific function of alpha 5 beta 1 integrin in microglial migration during early colonization of the developing mouse cortex. In: GLIA (New York, N.Y. : Print), 65(7), p. 1072-1088. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2018 | - |
crisitem.journal.issn | 0894-1491 | - |
crisitem.journal.eissn | 1098-1136 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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2017_Smolders_last author version.pdf | Peer-reviewed author version | 1.87 MB | Adobe PDF | View/Open |
Smolders_et_al-2017-Glia.pdf Restricted Access | Published version | 2.14 MB | Adobe PDF | View/Open Request a copy |
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