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http://hdl.handle.net/1942/24124
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DC Field | Value | Language |
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dc.contributor.author | PRAMANIK, Sumit | - |
dc.contributor.author | LOSADA-PEREZ, Patricia | - |
dc.contributor.author | REEKMANS, Gunter | - |
dc.contributor.author | CARLEER, Robert | - |
dc.contributor.author | D'OLIESLAEGER, Marc | - |
dc.contributor.author | VANDERZANDE, Dirk | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | ETHIRAJAN, Anitha | - |
dc.date.accessioned | 2017-08-07T12:01:38Z | - |
dc.date.available | 2017-08-07T12:01:38Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, 7, p. 1-9 (Art N° 46257) | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/1942/24124 | - |
dc.description.abstract | With recent advances in the field of diagnostics and theranostics, liposomal technology has secured a fortified position as a potential nanocarrier. Specifically, radiation/photo-sensitive liposomes containing photo-polymerizable cross-linking lipids are intriguing as they can impart the vesicles with highly interesting properties such as response to stimulus and improved shell stability. In this work, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine (DTPE) is used as a photo-polymerizable lipid to form functional hybrid-liposomes as it can form intermolecular cross-linking through the diacetylenic groups. Hybrid-liposomes were formulated using mixtures of DTPE and saturated lipids of different chain lengths (dipalmitoylphosphatidylcholine (DPPC) and dimirystoilphosphatidylcholine (DMPC)) at different molar ratios. The physico-chemical characteristics of the liposomes has been studied before and after UV irradiation using a combination of techniques: DSC, QCM-D and solid-state NMR. The results signify the importance of a subtle modification in alkyl chain length on the phase behavior of the hybrid-liposomes and on the degree of crosslinking in the shell. | - |
dc.description.sponsorship | The authors thank IOF funding of Hasselt University and the support from BELSPO via IAP Programme (P7/05). The authors are thankful to Prof. M. Van Bael for the access to the DLS device and to Martine Vanhamel for DSC measurements. A.E. was supported by a FWO (Research Foundation Flanders) post-doctoral fellowship. | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | - |
dc.title | Physicochemical characterizations of functional hybrid liposomal nanocarriers formed using photosensitive lipids | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 9 | - |
dc.identifier.spage | 1 | - |
dc.identifier.volume | 7 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Pramanik, Sumit Kumar; Losada-Perez, Patricia; Reekmans, Gunter; Carleer, Robert; D'Olieslaeger, Marc; Vanderzande, Dirk; Adriaensens, Peter; Ethirajan, Anitha] Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1 & Agoralaan D, B-3590 Diepenbeek, Belgium. [Pramanik, Sumit Kumar; Losada-Perez, Patricia; Reekmans, Gunter; Carleer, Robert; D'Olieslaeger, Marc; Vanderzande, Dirk; Adriaensens, Peter; Ethirajan, Anitha] IMEC, Associated Lab IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 46257 | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1038/srep46257 | - |
dc.identifier.isi | 000399011400001 | - |
item.validation | ecoom 2018 | - |
item.contributor | PRAMANIK, Sumit | - |
item.contributor | LOSADA-PEREZ, Patricia | - |
item.contributor | REEKMANS, Gunter | - |
item.contributor | CARLEER, Robert | - |
item.contributor | D'OLIESLAEGER, Marc | - |
item.contributor | VANDERZANDE, Dirk | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | ETHIRAJAN, Anitha | - |
item.accessRights | Open Access | - |
item.fullcitation | PRAMANIK, Sumit; LOSADA-PEREZ, Patricia; REEKMANS, Gunter; CARLEER, Robert; D'OLIESLAEGER, Marc; VANDERZANDE, Dirk; ADRIAENSENS, Peter & ETHIRAJAN, Anitha (2017) Physicochemical characterizations of functional hybrid liposomal nanocarriers formed using photosensitive lipids. In: SCIENTIFIC REPORTS, 7, p. 1-9 (Art N° 46257). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 2045-2322 | - |
crisitem.journal.eissn | 2045-2322 | - |
Appears in Collections: | Research publications |
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pramanik 1.pdf | Published version | 929.59 kB | Adobe PDF | View/Open |
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