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http://hdl.handle.net/1942/24148
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DC Field | Value | Language |
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dc.contributor.author | Marcq, Elly | - |
dc.contributor.author | Siozopoulou, Vasiliki | - |
dc.contributor.author | De Waele, Jorrit | - |
dc.contributor.author | van Audenaerde, Jonas | - |
dc.contributor.author | Zwaenepoel, Karen | - |
dc.contributor.author | SANTERMANS, Eva | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Pauwels, Patrick | - |
dc.contributor.author | van Meerbeeck, Jan P. | - |
dc.contributor.author | Smits, Evelien L. J. | - |
dc.date.accessioned | 2017-08-07T14:29:36Z | - |
dc.date.available | 2017-08-07T14:29:36Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | ONCOIMMUNOLOGY, 6(1), p. 1-11 (Art N° e1261241) | - |
dc.identifier.issn | 2162-402X | - |
dc.identifier.uri | http://hdl.handle.net/1942/24148 | - |
dc.description.abstract | Malignant pleural mesothelioma (MPM) is an aggressive cancer with a poor prognosis and an increasing incidence, for which novel therapeutic strategies are urgently required. Since the immune system has been described to play a presumed role in the protection against MPM, characterization of its tumor immune microenvironment (TME) and immune checkpoints can identify new immunotherapeutic targets and their predictive and/or prognostic value. To characterize the TME and the immune checkpoint expression profile, we performed immunohistochemistry (IHC) on formalin-fixed paraffin embedded (FFPE) tissue sections from 54 MPM patients (40 at time of diagnosis; 14 treated with chemotherapy). We stained for PD-1, PD-L1, TIM-3, LAG-3, CD4, CD8, CD45RO, granzyme B, FoxP3 and CD68. Furthermore, we analyzed the relationship between the immunological parameters and survival, as well as response to chemotherapy. We found that TIM-3, PD-1 and PD-L1 were expressed on both immune and tumor cells. Strikingly, PD-1 and PD-L1 expression on tumor cells was only seen in unpretreated samples. No LAG-3 expression was observed. CD45RO expression in the stroma was an independent negative predictive factor for response on chemotherapy, while CD4 and TIM-3 expression in lymphoid aggregates were independent prognostic factors for better outcome. Our data propose TIM-3 as a promising new target in mesothelioma. Chemotherapy influences the expression of immune checkpoints and therefore further research on the best combination treatment schedule is required. | - |
dc.description.sponsorship | This work was performed with the support of the Belgian Foundation Against Cancer (grant number: FA/2014/263), the Research Foundation Flanders (grant number: 1510215N), AstraZeneca and a Methusalem grant of the University of Antwerp and Hasselt awarded to Prof. Herman Goossens and Prof Geert Molenberghs. E. Marcq is research fellow of Flanders Innovation & Entrepreneurship (fellowship number: 141433), J. De Waele and J. Van Audenaerde of the Research Foundation Flanders (fellowship numbers: 1121016N and 1S32316N). | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.rights | © 2017 Taylor & Francis Group, LLC | - |
dc.subject.other | biomarkers; immune checkpoints; immunohistochemistry; mesothelioma; tumor microenvironment | - |
dc.subject.other | Biomarkers; immune checkpoints; immunohistochemistry; mesothelioma; tumor microenvironment | - |
dc.title | Prognostic and predictive aspects of the tumor immune microenvironment and immune checkpoints in malignant pleural mesothelioma | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 11 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 1 | - |
dc.identifier.volume | 6 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Marcq, Elly; Siozopoulou, Vasiliki; De Waele, Jorrit; van Audenaerde, Jonas; Zwaenepoel, Karen; Pauwels, Patrick; van Meerbeeck, Jan P.; Smits, Evelien L. J.] Univ Antwerp, Ctr Oncol Res, Antwerp, Belgium. [Siozopoulou, Vasiliki; Zwaenepoel, Karen; Pauwels, Patrick] Univ Antwerp Hosp, Dept Pathol, Antwerp, Belgium. [Santermans, Eva; Hens, Niel] Hasselt Univ, Interunivers Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, Niel] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modeling Infect Dis, Antwerp, Belgium. [van Meerbeeck, Jan P.] Univ Antwerp Hosp, MOCA, Thorac Oncol, Antwerp, Belgium. [Smits, Evelien L. J.] Univ Antwerp, Vaccine & Infect Dis Inst, Lab Expt Hematol, Antwerp, Belgium. | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e1261241 | - |
dc.identifier.doi | 10.1080/2162402X.2016.1261241 | - |
dc.identifier.isi | 000397069400023 | - |
item.fullcitation | Marcq, Elly; Siozopoulou, Vasiliki; De Waele, Jorrit; van Audenaerde, Jonas; Zwaenepoel, Karen; SANTERMANS, Eva; HENS, Niel; Pauwels, Patrick; van Meerbeeck, Jan P. & Smits, Evelien L. J. (2017) Prognostic and predictive aspects of the tumor immune microenvironment and immune checkpoints in malignant pleural mesothelioma. In: ONCOIMMUNOLOGY, 6(1), p. 1-11 (Art N° e1261241). | - |
item.validation | ecoom 2018 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | Marcq, Elly | - |
item.contributor | Siozopoulou, Vasiliki | - |
item.contributor | De Waele, Jorrit | - |
item.contributor | van Audenaerde, Jonas | - |
item.contributor | Zwaenepoel, Karen | - |
item.contributor | SANTERMANS, Eva | - |
item.contributor | HENS, Niel | - |
item.contributor | Pauwels, Patrick | - |
item.contributor | van Meerbeeck, Jan P. | - |
item.contributor | Smits, Evelien L. J. | - |
crisitem.journal.issn | 2162-402X | - |
crisitem.journal.eissn | 2162-402X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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marcq2016.pdf Restricted Access | Published version | 1.61 MB | Adobe PDF | View/Open Request a copy |
Revised Manuscript_2016ONCOIMM0498.pdf | Peer-reviewed author version | 892.66 kB | Adobe PDF | View/Open |
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