Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24156
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dc.contributor.authorDesmet, Lieven-
dc.contributor.authorVenet, David-
dc.contributor.authorDoffagne, Erik-
dc.contributor.authorTimmermans, Catherine-
dc.contributor.authorLEGRAND, Catherine-
dc.contributor.authorBURZYKOWSKI, Tomasz-
dc.contributor.authorBUYSE, Marc-
dc.date.accessioned2017-08-08T07:51:02Z-
dc.date.available2017-08-08T07:51:02Z-
dc.date.issued2017-
dc.identifier.citationSTATISTICS IN BIOPHARMACEUTICAL RESEARCH, 9(1), p. 1-11-
dc.identifier.issn1946-6315-
dc.identifier.urihttp://hdl.handle.net/1942/24156-
dc.description.abstractAs part of central statistical monitoring of multicenter clinical trial data, we propose a procedure based on the beta-binomial distribution for the detection of centers with atypical values for the probability of some event. The procedure makes no assumptions about the typical event proportion and uses the event counts from all centers to derive a reference model. The procedure is shown through simulations to have high sensitivity and high specificity if the contamination rate is small and the atypical event proportions are the result of some systematic shift in the underlying data-generating mechanism.-
dc.description.sponsorshipThe authors gratefully acknowledge financial support from the Walloon Government under the BioWin framework (Consortium agreement nr. 6741). Partial support for this research (Catherine Legrand and Tomasz Burzykowski) was provided by the IAP Research Network P7/06 of the Belgian State (Belgian Science Policy).-
dc.language.isoen-
dc.publisherAMER STATISTICAL ASSOC-
dc.subject.otherBeta-binomial; Central statistical monitoring; Error detection; Multicenter clinical trial-
dc.subject.otherbeta-binomial; central statistical monitoring; error detection; multicenter clinical trial-
dc.titleUse of the Beta-Binomial Model for Central Statistical Monitoring of Multicenter Clinical Trials-
dc.typeJournal Contribution-
dc.identifier.epage11-
dc.identifier.issue1-
dc.identifier.spage1-
dc.identifier.volume9-
local.format.pages11-
local.bibliographicCitation.jcatA1-
dc.description.notes[Desmet, Lieven; Timmermans, Catherine; Legrand, Catherine] Catholic Univ Louvain, ISBA, Louvain La Neuve, Belgium. [Venet, David] Univ Libre Bruxelles, IRIDIA, Brussels, Belgium. [Venet, David] Univ Libre Bruxelles, Inst Bordet, Breast Canc Translat Res Lab, Brussels, Belgium. [Doffagne, Erik] CluePoints SA, Louvain La Neuve, Belgium. [Timmermans, Catherine] Univ Liege, Dept Math, Liege, Belgium. [Burzykowski, Tomasz] IDDI, Louvain La Neuve, Belgium. [Burzykowski, Tomasz; Buyse, Marc] Hasselt Univ, I BioStat, Hasselt, Belgium. [Buyse, Marc] IDDI, Biostat, San Francisco, CA USA.-
local.publisher.placeALEXANDRIA-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1080/19466315.2016.1164751-
dc.identifier.isi000397258400001-
item.fulltextWith Fulltext-
item.contributorDesmet, Lieven-
item.contributorVenet, David-
item.contributorDoffagne, Erik-
item.contributorTimmermans, Catherine-
item.contributorLEGRAND, Catherine-
item.contributorBURZYKOWSKI, Tomasz-
item.contributorBUYSE, Marc-
item.fullcitationDesmet, Lieven; Venet, David; Doffagne, Erik; Timmermans, Catherine; LEGRAND, Catherine; BURZYKOWSKI, Tomasz & BUYSE, Marc (2017) Use of the Beta-Binomial Model for Central Statistical Monitoring of Multicenter Clinical Trials. In: STATISTICS IN BIOPHARMACEUTICAL RESEARCH, 9(1), p. 1-11.-
item.accessRightsOpen Access-
item.validationecoom 2018-
crisitem.journal.issn1946-6315-
crisitem.journal.eissn1946-6315-
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