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Title: | An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe | Authors: | RUTTENS, David Verleden, Stijn E. BIJNENS, Esmee WINCKELMANS, Ellen Gottlieb, Jens Warnecke, Gregor Meloni, Federica Morosini, Monica Van Der Bij, Wim Verschuuren, Erik A. Sommerwerck, Urte Weinreich, Gerhard Kamler, Markus Roman, Antonio Gomez-Olles, Susana Berastegui, Cristina Benden, Christian Holm, AreMartin Iversen, Martin Schultz, Hans Henrik Luijk, Bart Oudijk, Erik-Jan Erp, Johanna M. Kwakkel-van Jaksch, Peter Klepetko, Walter Kneidinger, Nikolaus Neurohr, Claus Corris, Paul Fisher, Andrew J. Lordan, James Meachery, Gerard Piloni, Davide Vandermeulen, Elly Bellon, Hannelore Hoffmann, Barbara Vienneau, Danielle Hoek, Gerard de Hoogh, Kees Nemery, Benoit Verleden, Geert M. Vos, Robin NAWROT, Tim Vanaudenaerde, Bart M. |
Issue Date: | 2017 | Publisher: | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Source: | EUROPEAN RESPIRATORY JOURNAL, 49(1), p. 1-8 (Art N° UNSP 1600484) | Abstract: | Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies. 13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter. 10 mu m (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway. After correction for macrolide use, we found associations between air pollution variables and CLAD/ mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.0851.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations. Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides. | Notes: | [Ruttens, David; Verleden, Stijn E.; Piloni, Davide; Vandermeulen, Elly; Bellon, Hannelore; Nemery, Benoit; Verleden, Geert M.; Vos, Robin; Vanaudenaerde, Bart M.] Katholieke Univ Leuven, Leuven, Belgium. [Bijnens, Esmee M.; Winckelmans, Ellen; Nawrot, Tims.] Hasselt Univ, Hasselt, Belgium. [Gottlieb, Jens; Warnecke, Gregor] Hannover Med Sch, Hannover, Germany. [Meloni, Federica; Morosini, Monica; Piloni, Davide] Univ Pavia, Pavia, Italy. [Van Der Bij, Wim; Verschuuren, Erik A.] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands. [Sommerwerck, Urte; Weinreich, Gerhard; Kamler, Markus] Univ Duisburg Essen, Univ Hosp Essen, Ruhrlandklin, Essen, Germany. [Roman, Antonio; Gomez-Olles, Susana; Berastegui, Cristina] Univ Autonoma Barcelona, Hosp Vall Hebron, Barcelona, Spain. [Roman, Antonio; Gomez-Olles, Susana] CIBER Enfermedades Resp CIBERES, Barcelona, Spain. [Benden, Christian] Univ Zurich Hosp, Zurich, Switzerland. [Holm, AreMartin] Univ Oslo, Oslo, Norway. [Holm, AreMartin] Oslo Univ Hosp, Dept Resp Med, Oslo, Norway. [Iversen, Martin; Schultz, Hans Henrik] Univ Copenhagen Hosp, Rigshosp, Copenhagen, Denmark. [Luijk, Bart; Oudijk, Erik-Jan; Erp, Johanna M. Kwakkel-van; Hoek, Gerard] St Antonius Hosp Nieuwegein, Univ Med Ctr Utrecht, Utrecht, Netherlands. [Jaksch, Peter; Klepetko, Walter] Univ Vienna, Vienna, Austria. [Kneidinger, Nikolaus; Neurohr, Claus] Klinikum Grosshadern LMU, Munich, Germany. [Fisher, Andrew J.; Lordan, James; Meachery, Gerard] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England. [Hoffmann, Barbara] Univ Klinikum Dusseldorf, Dusseldorf, Germany. [Vienneau, Danielle; de Hoogh, Kees] Swiss Trop & Publ Hlth Inst, Basel, Switzerland. [Vienneau, Danielle; de Hoogh, Kees] Univ Basel, Basel, Switzerland. | Document URI: | http://hdl.handle.net/1942/24159 | ISSN: | 0903-1936 | e-ISSN: | 1399-3003 | DOI: | 10.1183/13993003.00484-2016 | ISI #: | 000397423500011 | Rights: | Copyright ©ERS 2016 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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PMeuropa_nawrot.pdf | Peer-reviewed author version | 326.75 kB | Adobe PDF | View/Open |
1600484.full.pdf Restricted Access | Published version | 408.56 kB | Adobe PDF | View/Open Request a copy |
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