Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/24175
Title: | Perfusion of the uterine junctional zone in nulliparous and primiparous women assessed by DCE-MRI, as a function of menstrual cycle and hormonal contraception | Authors: | MEYLAERTS, Liesbeth Wijnen, L. Bazot, M. Grieten, M. OMBELET, Willem VANDERSTEEN, Marjan |
Issue Date: | 2017 | Publisher: | ELSEVIER SCIENCE INC | Source: | MAGNETIC RESONANCE IMAGING, 38, p. 101-111 | Abstract: | Purpose: To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Material and methods: We performed pelvic 1.5 T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26.4, 25.8, 3023 and 28.18 years). The nulliparous non-users underwent DCE-MRI investigations during their follicular, ovulatory and luteal phase. Perfusion parameters (iAUC/volume, Ktrans, Kep and Ve) were assessed in the anterior and posterior junctional zone (JZ), outer myometrium and cervix. Results: In nulliparous non-users, the mean Ktrans and iAUC/volume showed a decrease from follicular to luteal phase (0.82 vs 0.55 min(-1) for Ktrans, p = 0/027 and 1.28 vs 0.68 for iAUC/volume, p < 0.001). The anterior JZ demonstrated lower Ktrans (p = 0.050) and higher Kep (p = 0.012), in nulliparous non-users, lower Ktrans in nulliparous users (p < 0.001) and lower Ve in primiparous users (p = 0.012) than the anterior outer myometrium. Ktrans at the anterior and posterior JZ wall in nulliparous users was lower than in non-users (p = 0.001 and p = 0.013) and Ve at the anterior JZ wall in primiparous users was lower than in non-users (p = 0.044). Conclusion: This study provides data on normal perfusion parameters of inner and outer myometrium, which may be potentially useful in assisted reproductive therapy. (C) 2016 Elsevier Inc All rights reserved. | Notes: | [Meylaerts, L. J.; Wijnen, L.; Grieten, M.] Ziekenhuis Oost Limburg, Dept Med Imaging, Schiepse Bos 6, B-3600 Genk, Belgium. [Bazot, M.] Hop Tenon, Dept Radiol, Paris, France. [Ombelet, W.] Ziekenhuis Oost Limburg, Dept Obstet & Gynecol, Genk, Belgium. [Wijnen, L.; Vandersteen, M.] Hasselt Univ, Fac Med & Biomed, Diepenbeek, Belgium. | Keywords: | DCE-MRI; Perfusion; Junctional zone; Outer myometrium; Nulliparous; Primiparous;DCE-MRI; perfusion; junctional zone; outer myometrium; nulliparous; primiparous | Document URI: | http://hdl.handle.net/1942/24175 | ISSN: | 0730-725X | e-ISSN: | 1873-5894 | DOI: | 10.1016/j.mri.2016.12.026 | ISI #: | 000398008700015 | Rights: | © 2016 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
meylaerts 1.pdf Restricted Access | Published version | 2.58 MB | Adobe PDF | View/Open Request a copy |
Perfusion of the Uterine Junctional Zone in Nulliparous and Primiparous Women assessed by DCE.pdf | Peer-reviewed author version | 1.55 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
3
checked on Sep 7, 2020
WEB OF SCIENCETM
Citations
4
checked on Oct 12, 2024
Page view(s)
76
checked on Aug 2, 2022
Download(s)
264
checked on Aug 2, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.