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Title: | Phthalate-induced oxidative stress and association with asthma-related airway inflammation in adolescents | Authors: | Franken, Carmen Lambrechts, Nathalie Govarts, Eva Koppen, Gudrun Den Hond, Elly Ooms, Daniella Voorspoels, Stefan BRUCKERS, Liesbeth Loots, Ilse Nelen, Vera Sioen, Isabelle NAWROT, Tim Baeyens, Willy Van Larebeke, Nicolas Schoeters, Greet |
Issue Date: | 2017 | Publisher: | ELSEVIER GMBH, URBAN & FISCHER VERLAG | Source: | INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 220(2), p. 468-477 | Abstract: | Background: In Belgium, around 8.5% of the children have asthmatic symptoms. Increased asthma risk in children has been reported in relation to exposure to phthalate plasticizers but the underlying mechanisms are largely unknown. Aim: The aim of this study was to identify if oxidative stress, assessed by excision of 8-hydroxydeoxyguanosine (8-OHdG) from damaged DNA, is an intermediate marker for the association between phthalate exposure and doctor-diagnosed asthma. Material and methods: In 41814-15-year-old youngsters, recruited as a representative sample of residents of Flanders (Belgium), personal exposure to phthalates was assessed by measuring phthalate metabolites in urine: mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-n-butyl phthalate (MnBP), mono-benzyl phthalate (MBzP), mono-isobutyl phthalate (MiBP) and mono-ethyl phthalate (MEP). Analysis of 8-OHdG in urine was used as a sensitive biomarker of oxidative stress at the level of DNA. The presence of doctor diagnosed asthma was elicited by a self-administered questionnaire. Associations were assessed using multiple linear and logistic regression models. Mediation was tested using Baron and Kenny's regression approach. Results: A significant increased risk of a youngster being diagnosed with asthma was found for both urinary MnBP (metabolite of dibutyl phthalate (DBP)) and the sum of the three di(2-ethylhexyl) phthalate metabolites (Sigma DEHP = MEHP + MEHHP + MEOHP), with respective odds ratio of 1.84 [95% CI: 1.02,3.32] for MnBP and 1.94 [95% CI: 1.07, 3.51] for Sigma DEHP.In addition, we observed significant associations between all urinary phthalate metabolites and increased urinary levels of 8-OHdG. The associations were stronger in girls than in boys. We did not found evidence that 8-OHdG was associated with doctor-diagnosed asthma. Conclusion: The results of our study are in line with other findings from epidemiological surveys and raise further concern about DEHP and DBP as risk factors for asthma, however, the underlying mechanisms are not yet well understood. (C) 2017 Elsevier GmbH. All rights reserved. | Notes: | [Franken, Carmen; Lambrechts, Nathalie; Govarts, Eva; Koppen, Gudrun; Ooms, Daniella; Voorspoels, Stefan; Schoeters, Greet] Flemish Inst Technol Res VITO, Boeretang 200, B-2400 Mol, Belgium. [Franken, Carmen; Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium. [Den Hond, Elly; Nelen, Vera] Prov Inst Hyg, Antwerp, Belgium. [Bruckers, Liesbeth] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Loots, Ilse] Univ Antwerp, Polit & Social Sci, Antwerp, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Publ Hlth, Ghent, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Food Safety & Food Qual, Ghent, Belgium. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium. [Baeyens, Willy; Van Larebeke, Nicolas] Vrije Univ Brussel, Dept Analyt & Environm Chem, Brussels, Belgium. [Van Larebeke, Nicolas] Univ Ghent, Dept Radiotherapy & Nucl Med, Ghent, Belgium. [Schoeters, Greet] Univ Southern Denmark, Inst Publ Hlth, Dept Environm Med, Odense, Denmark. | Keywords: | Human biomonitoring; Oxidative stress; Phthalate; Doctor-diagnosed asthma; 8-hydroxydeoxyguanosine;human biomonitoring; oxidative stress; phthalate; doctor-diagnosed asthma; 8-hydroxydeoxyguanosine | Document URI: | http://hdl.handle.net/1942/24250 | ISSN: | 1438-4639 | e-ISSN: | 1618-131X | DOI: | 10.1016/j.ijheh.2017.01.006 | ISI #: | 000401215300018 | Rights: | © 2017 Elsevier GmbH. All rights reserved | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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