Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/24255
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Roobrouck, Valerie D. | - |
dc.contributor.author | WOLFS, Esther | - |
dc.contributor.author | Delforge, Michel | - |
dc.contributor.author | Broekaert, Dorien | - |
dc.contributor.author | Chakraborty, Soumen | - |
dc.contributor.author | Sels, Kathleen | - |
dc.contributor.author | Vanwelden, Thomas | - |
dc.contributor.author | Holvoet, Bryan | - |
dc.contributor.author | Lhoest, Larissa | - |
dc.contributor.author | Khurana, Satish | - |
dc.contributor.author | Pandey, Shubham | - |
dc.contributor.author | Hoornaert, Chloe | - |
dc.contributor.author | Ponsaerts, Peter | - |
dc.contributor.author | STRUYS, Tom | - |
dc.contributor.author | Boeckx, Nancy | - |
dc.contributor.author | Vandenberghe, Peter | - |
dc.contributor.author | Deroose, Christophe M. | - |
dc.contributor.author | Verfaillie, Catherine M. | - |
dc.date.accessioned | 2017-08-17T13:52:47Z | - |
dc.date.available | 2017-08-17T13:52:47Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | CYTOTHERAPY, 19(6), p. 744-755 | - |
dc.identifier.issn | 1465-3249 | - |
dc.identifier.uri | http://hdl.handle.net/1942/24255 | - |
dc.description.abstract | Background aims. Myelodysplastic syndromes (MDS) are a group of clonal stem cell disorders affecting the normal hematopoietic differentiation process and leading to abnormal maturation and differentiation of all blood cell lineages. Treatment options are limited, and there is an unmet medical need for effective therapies for patients with severe cytopenias. Methods. We demonstrate that multipotent adult progenitor cells (MAPC) improve the function of hematopoietic progenitors derived from human MDS bone marrow (BM) by significantly increasing the frequency of primitive progenitors as well as the number of myeloid colonies. Results. This effect was more pronounced in a non-contact culture, indicating the importance of soluble factors produced by the MAPC cells. Moreover, the cells did not stimulate the growth of the abnormal MDS clone, as shown by fluorescent in situ hybridization analysis on BM cells from patients with a known genetic abnormality. We also demonstrate that MAPC cells can provide stromal support for patient-derived hematopoietic cells. When MAPC cells were intravenously injected into a mouse model of MDS, they migrated to the site of injury and increased the hematopoietic function in diseased mice. Discussion. The preclinical studies undertaken here indicate an initial proof of concept for the use of MAPC cell therapy in patients with MDS-related severe and symptomatic cytopenias and should pave the way for further investigation in clinical trials. | - |
dc.description.sponsorship | This work was supported by research grants from FWO Vlaanderen (Kom op tegen kanker; G.0693.12) en de Stichting tegen kanker (2012-194) to CMV, and the CAF-DCF Fractionation Unit of the Belgian Red Cross (G.0D17.15) to MD. Personal grants from the Flemish Institute for Science and Technology (IWT Vlaanderen) were granted to VDR and BH. PV is a Senior Clinical Investigator at FWO Vlaanderen. We thank Ursula Pluys en Heidi Lemmens from the Center of Human Genetics (UZ Leuven) for expert assistance with the FISH protocol. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.rights | © 2017 Published by Elsevier Inc. on behalf of International Society for Cellular Therapy | - |
dc.subject.other | cell therapy; multipotent adult progenitor cells; myelodysplasia | - |
dc.subject.other | cell therapy; multipotent adult progenitor cells; myelodysplasia | - |
dc.title | Multipotent adult progenitor cells improve the hematopoietic function in myelodysplasia | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 755 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 744 | - |
dc.identifier.volume | 19 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Roobrouck, Valerie D.; Delforge, Michel; Broekaert, Dorien; Sels, Kathleen; Vanwelden, Thomas; Lhoest, Larissa; Khurana, Satish; Pandey, Shubham; Verfaillie, Catherine M.] Katholieke Univ Leuven, Dept Dev & Regenerat, Unit Embryol & Stem Cell Biol, Stem Cell Inst Leuven, O&N4 Box 804,Herestr 49, B-3000 Leuven, Belgium. [Wolfs, Esther; Holvoet, Bryan; Deroose, Christophe M.] Katholieke Univ Leuven, Nucl Med & Mol Imaging & Mol Small Anim Imaging C, Dept Imaging & Pathol, Leuven, Belgium. [Wolfs, Esther; Struys, Tom] Univ Hasselt, Biomed Res Inst, Morphol Res Grp, Diepenbeek, Belgium. [Delforge, Michel; Vandenberghe, Peter] Univ Hosp Leuven, Dept Hematol, Leuven, Belgium. [Chakraborty, Soumen] Inst Life Sci, Dept Gene Funct & Regulat, Bhubaneswar, Orissa, India. [Hoornaert, Chloe] Univ Antwerp, Vaccine & Infect Dis Inst, Lab Expt Hematol, Antwerp, Belgium. [Ponsaerts, Peter; Boeckx, Nancy] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium. [Boeckx, Nancy] Katholieke Univ Leuven, Dept Oncol, Leuven, Belgium. [Vandenberghe, Peter] Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium. [Roobrouck, Valerie D.] ReGenesys, Heverlee, Belgium. [Khurana, Satish] Indian Inst Sci Educ & Res, Thiruvananthapuram, Kerala, India. | - |
local.publisher.place | OXFORD | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jcyt.2017.03.009 | - |
dc.identifier.isi | 000402027200009 | - |
item.accessRights | Restricted Access | - |
item.contributor | Roobrouck, Valerie D. | - |
item.contributor | WOLFS, Esther | - |
item.contributor | Delforge, Michel | - |
item.contributor | Broekaert, Dorien | - |
item.contributor | Chakraborty, Soumen | - |
item.contributor | Sels, Kathleen | - |
item.contributor | Vanwelden, Thomas | - |
item.contributor | Holvoet, Bryan | - |
item.contributor | Lhoest, Larissa | - |
item.contributor | Khurana, Satish | - |
item.contributor | Pandey, Shubham | - |
item.contributor | Hoornaert, Chloe | - |
item.contributor | Ponsaerts, Peter | - |
item.contributor | STRUYS, Tom | - |
item.contributor | Boeckx, Nancy | - |
item.contributor | Vandenberghe, Peter | - |
item.contributor | Deroose, Christophe M. | - |
item.contributor | Verfaillie, Catherine M. | - |
item.fullcitation | Roobrouck, Valerie D.; WOLFS, Esther; Delforge, Michel; Broekaert, Dorien; Chakraborty, Soumen; Sels, Kathleen; Vanwelden, Thomas; Holvoet, Bryan; Lhoest, Larissa; Khurana, Satish; Pandey, Shubham; Hoornaert, Chloe; Ponsaerts, Peter; STRUYS, Tom; Boeckx, Nancy; Vandenberghe, Peter; Deroose, Christophe M. & Verfaillie, Catherine M. (2017) Multipotent adult progenitor cells improve the hematopoietic function in myelodysplasia. In: CYTOTHERAPY, 19(6), p. 744-755. | - |
item.validation | ecoom 2018 | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1465-3249 | - |
crisitem.journal.eissn | 1477-2566 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
aaa.pdf Restricted Access | Published version | 1.73 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
1
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
3
checked on Apr 14, 2024
Page view(s)
66
checked on Sep 7, 2022
Download(s)
40
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.