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Title: Multiple confidence intervals for selected parameters adjusted for the false coverage rate in monotone dose-response microarray experiments
Authors: Peng, Jianan
Liu, Wei
Bretz, Frank
Issue Date: 2017
Publisher: WILEY
Source: BIOMETRICAL JOURNAL, 59(4), p. 732-745
Abstract: Benjamini and Yekutieli () introduced the concept of the false coverage-statement rate (FCR) to account for selection when the confidence intervals (CIs) are constructed only for the selected parameters. Dose-response analysis in dose-response microarray experiments is conducted only for genes having monotone dose-response relationship, which is a selection problem. In this paper, we consider multiple CIs for the mean gene expression difference between the highest dose and control in monotone dose-response microarray experiments for selected parameters adjusted for the FCR. A simulation study is conducted to study the performance of the method proposed. The method is applied to a real dose-response microarray experiment with 16, 998 genes for illustration.
Notes: [Peng, Jianan] Acadia Univ, Dept Math & Stat, Wolfville, NS B4P 2R6, Canada. [Liu, Wei] Univ Southampton, S3RI, Southampton SO17 1BJ, Hants, England. [Liu, Wei] Univ Southampton, Sch Math, Southampton SO17 1BJ, Hants, England. [Bretz, Frank] Novartis Pharma AG, CH-4002 Basel, Switzerland. [Bretz, Frank] Shanghai Univ Finance & Econ, Sch Stat & Management, Shanghai, Peoples R China. [Shkedy, Ziv] Univ Hasselt, Ctr Stat CenStat, BioStat 1, Campus Diepenbeek,Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium.
Keywords: dose-response study; FCR; FDR; order-restricted inference; selective inference;Dose-response study; FCR; FDR; Order-restricted inference; Selective inference
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ISSN: 0323-3847
e-ISSN: 1521-4036
DOI: 10.1002/bimj.201500254
ISI #: 000404907800010
Rights: (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Category: A1
Type: Journal Contribution
Validations: ecoom 2018
Appears in Collections:Research publications

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