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Title: | Predictive factors influencing pregnancy rates after intrauterine insemination with frozen donor semen: a prospective cohort study | Authors: | THIJSSEN, Annelies CREEMERS, An VAN DER ELST, Wim Creemers, Eva Vandormael, Eva Dhont, Nathalie OMBELET, Willem |
Issue Date: | 2017 | Publisher: | ELSEVIER SCI LTD | Source: | REPRODUCTIVE BIOMEDICINE ONLINE, 34(6), p. 590-597 | Abstract: | The extent to which certain parameters can influence pregnancy rates after intrauterine insemination with frozen donor semen was examined prospectively. Between July 2011 and September 2015, 402 women received 126410 cycles with frozen donor semen in a tertiary referral infertility centre. A case report form was used to collect data prospectively. The primary outcome measure was clinical pregnancy rate (CPR), confirmed by detection of a gestational sac and fetal heartbeat using ultrasonography at 7-8 weeks of gestation. Statistical analysis was carried out using generalized estimating equations (GEE) to account for the correlation between observations from the same patient. Overall, CPR per cycle was 17.2%. Multivariate GEE analysis revealed the following parameters as predictive for a successful pregnancy outcome: female age (P = 0.0003), non-smoking or smoking fewer than 15 cigarettes a day (P = 0.0470 and P = 0.0235, respectively), secondary infertility (P = 0.0062), low progesterone levels at day zero of the cycle (P = 0.0164) and use of ovarian stimulation with HMG and recombinant FSH compared with clomiphene citrate and natural cycle (P = 0.0006 and P = 0.0004, respectively). These parameters were the most important factors influencing the success rate in a sperm donation programme. | Notes: | [Thijssen, Annelies; Creemers, Eva; Vandormael, Eva; Dhont, Nathalie; Ombelet, Willem] Genk Inst Fertil Technol, Dept Obstet & Gynecol, Schiepse Bos 6, B-3600 Genk, Belgium. [Thijssen, Annelies; Ombelet, Willem] Hasselt Univ, Dept Physiol, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Creemers, An; Van der Elst, Wim] Hasselt Univ, Ctr Stat CENSTAT, Agoralaan Bldg, B-3590 Diepenbeek, Belgium. | Keywords: | Donor sperm; IUI; Prognostic factor; Prospective cohort study; Success rate;donor sperm; IUI; prognostic factor; prospective cohort study; success rate | Document URI: | http://hdl.handle.net/1942/24387 | ISSN: | 1472-6483 | e-ISSN: | 1472-6491 | DOI: | 10.1016/j.rbmo.2017.03.012 | ISI #: | 000407004600007 | Rights: | (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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