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Title: | The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service | Authors: | Vranken, Lisanne Wyers, Caroline E. VAN DEN BERGH, Joop GEUSENS, Piet |
Issue Date: | 2017 | Publisher: | SPRINGER | Source: | CALCIFIED TISSUE INTERNATIONAL, 101(3), p. 248-258 | Abstract: | The aetiology of fractures in patients aged 50 years and older is multifactorial, and includes bone- and fall-related risks. The Fracture Liaison Service (FLS) is recommended to identify patients with a recent fracture and to evaluate their subsequent fracture risk, in order to take measures to decrease the risk of subsequent fractures in patients with a high risk phenotype. A literature survey was conducted to describe components of the bone- and fall-related phenotype of patients attending the FLS. Components of the patient phenotype at the FLS have been reported in 33 studies. Patient selection varied widely in terms of patient identification, selection, and FLS attendance. Consequently, there was a high variability in FLS patient characteristics, such as mean age (64-80 years), proportion of men (13-30%), and fracture locations (2-51% hip, < 1-41% vertebral, and 49-95% non-hip, non-vertebral fractures). The studies also varied in the risk evaluation performed. When reported, there was a highly variability in the percentage of patients with osteoporosis (12-54%), prevalent vertebral fractures (20-57%), newly diagnosed contributors to secondary osteoporosis and metabolic bone disorders (3-70%), and fall-related risk factors (60-84%). In FLS literature, we found a high variability in patient selection and risk evaluation, resulting in a highly variable phenotype. In order to specify the bone- and fall related phenotypes at the FLS, systematic studies on the presence and combinations of these risks are needed. | Notes: | [Vranken, Lisanne; Wyers, Caroline E.; van den Bergh, Joop P. W.] VieCuri Med Ctr, Dept Internal Med, POB 1926, NL-5900 BX Venlo, Netherlands. [Vranken, Lisanne; Wyers, Caroline E.; van den Bergh, Joop P. W.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Internal Med, Med Ctr MUMC, POB 616, NL-6200 MD Maastricht, Netherlands. [van den Bergh, Joop P. W.; Geusens, Piet P. M. M.] Hasselt Univ, Biomed Res Ctr, Agoralaan, B-3590 Diepenbeek, Belgium. [Geusens, Piet P. M. M.] Maastricht Univ, Dept Internal Med, Subdiv Rheumatol, CAPHRI,Med Ctr MUMC, POB 616, NL-6200 MD Maastricht, Netherlands. | Keywords: | Fracture Liaison Service; Fractures; Secondary prevention; Phenotype;fracture Liaison Service; fractures; secondary prevention; phenotype | Document URI: | http://hdl.handle.net/1942/24417 | ISSN: | 0171-967X | e-ISSN: | 1432-0827 | DOI: | 10.1007/s00223-017-0284-1 | ISI #: | 000407303100002 | Rights: | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://crea tivecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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