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Title: | Mother's Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort | Authors: | TSAMOU, Maria MARTENS, Dries WINCKELMANS, Ellen MADHLOUM, Narjes COX, Bianca GYSELAERS, Wilfried NAWROT, Tim VRIJENS, Karen |
Issue Date: | 2017 | Publisher: | NATURE PUBLISHING GROUP | Source: | SCIENTIFIC REPORTS, 7, p. 1-11 (Art N° 5548) | Abstract: | There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child's predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity. Multiple linear regression models were used to address the associations between pre-pregnancy BMI and placental candidate miRNA expression. Maternal pre-pregnancy BMI averaged (+/- SD) 23.9 (+/- 4.1) kg/m(2). In newborn girls ( not in boys) placental miR-20a, miR-34a and miR-222 expression was lower with higher maternal pre-pregnancy BMI. In addition, the association between maternal pre-pregnancy BMI and placental expression of these miRNAs in girls was modified by gestational weight gain. The lower expression of these miRNAs in placenta in association with pre-pregnancy BMI, was only evident in mothers with low weight gain (< 14 kg). The placental expression of miR-20a, miR-34a, miR-146a, miR-210 and miR-222 may provide a sex-specific basis for epigenetic effects of pre-pregnancy BMI. | Notes: | [Tsamou, Maria; Martens, Dries S.; Winckelmans, Ellen; Madhloum, Narjes; Cox, Bianca; Nawrot, Tim S.; Vrijens, Karen] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Gyselaers, Wilfried] East Limburg Hosp, Dept Obstet, Genk, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Leuven Univ, Environm & Hlth Unit, Dept Publ Hlth, Leuven, Belgium. | Document URI: | http://hdl.handle.net/1942/24441 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-04026-8 | ISI #: | 000405675400028 | Rights: | © The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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tsamou 1.pdf | Published version | 1.58 MB | Adobe PDF | View/Open |
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