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Title: | CHADS(2) risk score and rate of stroke or systemic embolism and major bleeding in patients with non-valvular atrial fibrillation receiving non-vitamin K antagonist oral anticoagulants | Authors: | VAN MIEGHEM, Walter Lancellotti, Patrizio |
Issue Date: | 2017 | Publisher: | TAYLOR & FRANCIS LTD | Source: | ACTA CARDIOLOGICA, 72(4), p. 390-396 | Abstract: | Randomized trials showed non-inferior or superior results of the non-vitamin K antagonist oral anticoagulants (NOACs) compared with warfarin in patients with non-valvular atrial fibrillation (AF). Despite the absence of direct head-to-head comparisons between the different NOACs, certain molecules have been proposed for subgroups of patients based mainly on the perception of different bleeding risks. The CHADS(2) score has been uniformly used in the inclusion criteria of these studies and shared similar risk factors as the haemorrhagic risk score HAS-BLED. The aim of the present report was to highlight the relationships between CHADS(2) score and the rate of stroke or systemic embolism, and the rate of major bleeding in patients with AF on treatment with NOACs. Overall, in all the available randomized studies, a fairly good continuous relationship was observed between the CHADS(2) risk score and the rate of stroke or systemic embolism, and the rate of major bleeding in the different studies. Larger registries are needed to confirm this hypothesis. | Notes: | [Van Mieghem, Walter] Univ Hasselt, Hasselt, Belgium. [Lancellotti, Patrizio] Univ Liege Hosp, GIGA Cardiovasc Sci, Dept Cardiol, Heart Valve Clin,CHU Sart Tilman, Liege, Belgium. [Lancellotti, Patrizio] Anthea Hosp, Grp Villa Maria Care & Res, Bari, Italy. | Keywords: | Atrial fibrillation; CHADS(2) score; NOACs; stroke; major bleeding;atrial fibrillation; CHADS(2) score; NOACs; stroke; major bleeding | Document URI: | http://hdl.handle.net/1942/24455 | ISSN: | 0001-5385 | e-ISSN: | 1784-973X | DOI: | 10.1080/00015385.2017.1327248 | ISI #: | 000408014600004 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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