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Title: | Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites | Authors: | Tajebe, Fitsumbrhan Getahun, Mulusew Adem, Emebet Hailu, Asrat Lemma, Mulualem Fikre, Helina Raynes, John Tamiru, Aschalew Mulugeta, Zemenay Diro, Ermias Toulza, Frederic SHKEDY, Ziv Ayele, Tadesse Modolell, Manuel Munder, Markus Mueller, Ingrid Takele, Yegnasew Kropf, Pascale |
Issue Date: | 2017 | Publisher: | PUBLIC LIBRARY SCIENCE | Source: | PLOS NEGLECTED TROPICAL DISEASES, 11(7), p. 1-16 | Abstract: | Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity. | Notes: | [Tajebe, Fitsumbrhan; Getahun, Mulusew] Univ Gondar, Dept Immunol & Mol Biol, Gondar, Ethiopia. [Adem, Emebet; Fikre, Helina; Tamiru, Aschalew; Mulugeta, Zemenay; Diro, Ermias; Takele, Yegnasew] Univ Gondar, Leishmaniasis Res & Treatment Ctr, Gondar, Ethiopia. [Hailu, Asrat] Univ Addis Ababa, Dept Microbiol Immunol & Parasitol, Addis Ababa, Ethiopia. [Lemma, Mulualem; Diro, Ermias] Univ Gondar, Dept Internal Med, Gondar, Ethiopia. [Raynes, John] London Sch Hyg & Trop Med, Dept Immunol & Infect, London, England. [Toulza, Frederic] Kings Coll London, Fac Life Sci, Dept Haematol Med, London, England. [Shkedy, Ziv; Ayele, Tadesse] Univ Hasselt, Dept Math & Stat, Hasselt, Belgium. [Modolell, Manuel] Max Planck Inst Immunobiol & Epigenet, Dept Cellular Immunol, Freiburg, Germany. [Munder, Markus] Univ Med Ctr Mainz, Dept Med Hematol Oncol & Pneumol 3, Mainz, Germany. [Mueller, Ingrid; Takele, Yegnasew; Kropf, Pascale] Imperial Coll London, Dept Med, London, England. [Getahun, Mulusew] Ethiopian Publ Hlth Inst, Addis Ababa, Ethiopia. | Document URI: | http://hdl.handle.net/1942/24456 | ISSN: | 1935-2735 | e-ISSN: | 1935-2735 | DOI: | 10.1371/journal.pntd.0005727 | ISI #: | 000408057300039 | Rights: | © 2017 Tajebe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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