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http://hdl.handle.net/1942/2545
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DC Field | Value | Language |
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dc.contributor.author | Fischler, Benjamin | - |
dc.contributor.author | Tack, Jan | - |
dc.contributor.author | De Gucht, Véronique | - |
dc.contributor.author | SHKEDY, Ziv | - |
dc.contributor.author | Persoons, Philippe | - |
dc.contributor.author | Broekaert, Dorine | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | JANSSEN, Jo | - |
dc.date.accessioned | 2007-11-15T10:04:07Z | - |
dc.date.available | 2007-11-15T10:04:07Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | GASTROENTEROLOGY, 124(4). p. 903-910 | - |
dc.identifier.issn | 0016-5085 | - |
dc.identifier.uri | http://hdl.handle.net/1942/2545 | - |
dc.description.abstract | Background & Aims: Categorization of functional dyspepsia into subgroups is based on expert opinion according to (dominant) symptoms or on underlying pathophysiological mechanisms. We used an evidence-based approach to the determination of subtypes of functional dyspepsia. Methods: Consecutive functional dyspepsia patients were recruited from a tertiary referral center. The following were performed: (1) exploratory (EFA) and confirmatory factor analysis (CFA) of symptom patterns in a large group of patients with functional dyspepsia; (2) external validation of these factors by the determination of their association pattern with physio- and psychopathological mechanisms, and with health-related quality of life and sickness behavior; and (3) cluster analysis of their distribution in this population. Results: Both EFA and CFA do not support the existence of functional dyspepsia as a homogeneous (unidimensional) condition. A 4-factor model is found to be valid, with differential distribution within the patient population according to cluster analysis. Factor 1 is characterized by nausea, vomiting, early satiety, and weight loss and factor 2 by postprandial fullness and bloating. Both factor 1 and 2 are associated with delayed emptying, but only factor 1 is associated with younger age, female sex, and sickness behavior. Factor 3 is characterized by pain symptoms and associated with gastric hypersensitivity and several psychosocial dimensions including medically unexplained symptoms and health-related quality of life dimensions. Factor 4, characterized by belching, is also associated with hypersensitivity, but is unrelated to psychosocial dimensions. Conclusions: In a tertiary care population, functional dyspepsia is a heterogeneous condition characterized by 4 major dimensions differentially associated with psychopathological and physiopathological mechanisms. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | © 2003 by the American Gastroenterological Associatio | - |
dc.title | Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 910 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 903 | - |
dc.identifier.volume | 124 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Univ Hosp Gasthuisberg, Div Gastroenterol, Dept Internal Med, B-3000 Louvain, Belgium. Univ Hosp Gasthuisberg, Dept Psychiat, B-3000 Louvain, Belgium. Katholieke Univ Leuven, Dept Neurosci & Psychiat, Louvain, Belgium. Limburgs Univ Ctr, Ctr Stat, Diepenbeek, Belgium.Tack, J, Univ Hosp Gasthuisberg, Div Gastroenterol, Dept Internal Med, Herestr 49, B-3000 Louvain, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1053/gast.2003.50155 | - |
dc.identifier.isi | 000182002700010 | - |
item.contributor | Fischler, Benjamin | - |
item.contributor | Tack, Jan | - |
item.contributor | De Gucht, Véronique | - |
item.contributor | SHKEDY, Ziv | - |
item.contributor | Persoons, Philippe | - |
item.contributor | Broekaert, Dorine | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | JANSSEN, Jo | - |
item.validation | ecoom 2004 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Fischler, Benjamin; Tack, Jan; De Gucht, Véronique; SHKEDY, Ziv; Persoons, Philippe; Broekaert, Dorine; MOLENBERGHS, Geert & JANSSEN, Jo (2003) Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia. In: GASTROENTEROLOGY, 124(4). p. 903-910. | - |
crisitem.journal.issn | 0016-5085 | - |
crisitem.journal.eissn | 1528-0012 | - |
Appears in Collections: | Research publications |
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fischler2003.pdf Restricted Access | Published version | 128.21 kB | Adobe PDF | View/Open Request a copy |
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