Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/25589
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | GERVOIS, Pascal | - |
dc.contributor.author | DILLEN, Yorg | - |
dc.contributor.author | VANGANSEWINKEL, Tim | - |
dc.contributor.author | HILKENS, Petra | - |
dc.contributor.author | DRIESEN, Ronald | - |
dc.contributor.author | MERCKX, Greet | - |
dc.contributor.author | LO MONACO, Melissa | - |
dc.contributor.author | RATAJCZAK, Jessica | - |
dc.contributor.author | BRONCKAERS, Annelies | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | WOLFS, Esther | - |
dc.date.accessioned | 2018-03-01T13:50:43Z | - |
dc.date.available | 2018-03-01T13:50:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Lapchak, Paul A.; Zhang, John H. (Ed.). Cellular and Molecular Approaches to Regeneration and Repair, Springer International Publishing, p. 21-45 | - |
dc.identifier.isbn | 9783319666785 | - |
dc.identifier.issn | 2363-958X | - |
dc.identifier.uri | http://hdl.handle.net/1942/25589 | - |
dc.description.abstract | Worldwide, stroke is the second single most common cause of death and is a major cause of permanent disability. Moreover, the highest incidence of these pathologies is observed in the elderly, increasing the socioeconomic burden in an aging population. Current available therapies lead to insufficient functional improvement or are not applicable to all patients. This stresses the urgent need for alternative strategies in treating stroke patients, for example cell-based therapies. These cells showed great preclinical potential although the underlying therapeutic mechanisms, preferential route of administration and most suitable stem cell-subtype are unknown. Mechanisms of action include neuroprotection, cell replacement, neurogenesis, immunomodulation and the promotion of both neuroplasticity and angiogenesis in damaged central nervous system regions. Moreover, stem cells have been genetically engineered to enhance their beneficial effects after transplantation. Additionally, noninvasive imaging can be used to provide detailed spatial and functional information on the donor cell fate and the response of the host microenvironment. This chapter provides an overview of recent advances in (bio-)medical research using or manipulating stem cell-based therapies for ischaemic stroke with a focus on their neuroprotective, neuroregenerative and immunomodulatory properties. Additionally, the use of noninvasive imaging to allow temporospatial evaluation of stem cell fate following transplantation in animal stroke models will be discussed. | - |
dc.description.sponsorship | Pascal Gervois, Esther Wolfs, Jessica Ratajczak, Tim Vangansewinkel, Petra Hilkens, Yörg Dillen and Annelies Bronckaers are funded by Fonds Wetenschappelijk Onderzoek Vlaanderen by grants 12U7718N, G0A7514N, G089213N, G029112N, 12D8516N, 1134717N and 1508015N respectively. Greet Merckx and Melissa Lo Monaco are funded by Bijzonder Onderzoeksfonds grants BOF16DOC06 and BOF16DOCNA02 respectively. | - |
dc.language.iso | en | - |
dc.publisher | Springer International Publishing | - |
dc.relation.ispartofseries | Springer Series in Translational Stroke Research | - |
dc.rights | © Springer International Publishing AG 2018 | - |
dc.subject.other | stem cell; ischaemic stroke; noninvasive imaging; gene therapy; regenerative medicine; immunomodulation | - |
dc.title | Interdisciplinary advances towards understanding and enhancing the therapeutic potential of stem cell-based therapies for ischaemic stroke | - |
dc.type | Book Section | - |
local.bibliographicCitation.authors | Lapchak, Paul A.; Zhang, John H. | - |
dc.identifier.epage | 45 | - |
dc.identifier.spage | 21 | - |
local.bibliographicCitation.jcat | B2 | - |
local.publisher.place | Cham, Switzerland | - |
local.type.refereed | Refereed | - |
local.type.specified | Book Section | - |
local.identifier.vabb | c:vabb:437590 | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1007/978-3-319-66679-2_2 | - |
local.bibliographicCitation.btitle | Cellular and Molecular Approaches to Regeneration and Repair | - |
item.contributor | GERVOIS, Pascal | - |
item.contributor | DILLEN, Yorg | - |
item.contributor | VANGANSEWINKEL, Tim | - |
item.contributor | HILKENS, Petra | - |
item.contributor | DRIESEN, Ronald | - |
item.contributor | MERCKX, Greet | - |
item.contributor | LO MONACO, Melissa | - |
item.contributor | RATAJCZAK, Jessica | - |
item.contributor | BRONCKAERS, Annelies | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | WOLFS, Esther | - |
item.fulltext | With Fulltext | - |
item.validation | vabb 2019 | - |
item.fullcitation | GERVOIS, Pascal; DILLEN, Yorg; VANGANSEWINKEL, Tim; HILKENS, Petra; DRIESEN, Ronald; MERCKX, Greet; LO MONACO, Melissa; RATAJCZAK, Jessica; BRONCKAERS, Annelies; LAMBRICHTS, Ivo & WOLFS, Esther (2017) Interdisciplinary advances towards understanding and enhancing the therapeutic potential of stem cell-based therapies for ischaemic stroke. In: Lapchak, Paul A.; Zhang, John H. (Ed.). Cellular and Molecular Approaches to Regeneration and Repair, Springer International Publishing, p. 21-45. | - |
item.accessRights | Restricted Access | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
PGervois2017_Translational stroke research_Book Chapter.pdf Restricted Access | Published version | 397.31 kB | Adobe PDF | View/Open Request a copy |
Page view(s)
102
checked on May 31, 2022
Download(s)
128
checked on May 31, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.