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http://hdl.handle.net/1942/25613
Title: | Perception of induced dyspnea in fibromyalgia and chronic fatigue syndrome | Authors: | VAN DEN HOUTE, Maaike BOGAERTS, Katleen Van Diest, Ilse De Bie, Jozef Persoons, Philippe Van Oudenhove, Lukas Van den Bergh, Omer |
Issue Date: | 2018 | Source: | JOURNAL OF PSYCHOSOMATIC RESEARCH, 106, p. 49-55 | Status: | In Press | Abstract: | Objective: Dyspnea perception is distorted in patients with medically unexplained dyspnea. The goals of this study were 1) to replicate these results in patients with fibromyalgia and/or chronic fatigue syndrome (CFS), and 2) to investigate predictors of distorted symptom perception within the patient group, with a focus on negative affectivity (NA), psychiatric comorbidity and somatic symptom severity. Methods: Seventy-three patients diagnosed with fibromyalgia and/or CFS and 38 healthy controls (HC) completed a rebreathing paradigm, consisting of a baseline (60s of room air), a rebreathing phase (150s, gradually increasing ventilation, partial pressure of CO2 in the blood, and self-reported dyspnea), and a recovery phase (150s of room air). Dyspnea, respiratory flow and FetCO2 levels were measured continuously. Results: Patients reported more dyspnea than HC in the recovery phase (p = 0.039), but no differences between patients and HC were found in the baseline (p = 0.07) or rebreathing phase (p = 0.17). No significant differences between patients and HC were found in physiological reactivity. Within the patient group, the effect in the recovery phase was predicted by somatic symptom severity (p = 0.046), but not by negative affectivity or by the number of psychiatric comorbidities. Conclusion: This study extended earlier findings in patients with medically unexplained dyspnea to patients with fibromyalgia and CFS. This suggests that altered symptom perception is a non-symptom-specific mechanism underlying functional somatic syndromes in general, particularly in patients with high levels of somatic symptom severity . The results are discussed in a predictive coding framework of symptom perception. | Notes: | Van den Bergh, O (reprint author), Univ Leuven, KU Leuven, Tiensestr 102, B-3000 Leuven, Belgium, maaike.vandenhoute@kuleuven.be; katleen.bogaerts@kuleuven.be; ilse.vandiest@kuleuven.be; Jozef.DeBie@zol.be; philippe.persoons@kuleuven.be; lukas.vanoudenhove@kuleuven.be; omer.vandenbergh@ppw.kuleuven.be | Keywords: | functional somatic syndromes; fibromyalgia; chronic fatigue syndrome; symptom perception; predictive coding | Document URI: | http://hdl.handle.net/1942/25613 | ISSN: | 0022-3999 | e-ISSN: | 1879-1360 | DOI: | 10.1016/j.jpsychores.2018.01.007. | ISI #: | 000426335100007 | Rights: | © 2018 Published by Elsevier Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Rebreathing_accepted.pdf | Peer-reviewed author version | 739.01 kB | Adobe PDF | View/Open |
10.1016@j.jpsychores.2018.01.007.pdf Restricted Access | Published version | 645.74 kB | Adobe PDF | View/Open Request a copy |
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