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DC Field | Value | Language |
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dc.contributor.author | WILLEBRAND, Ralf | - |
dc.contributor.author | KLEINEWIETFELD, Markus | - |
dc.date.accessioned | 2018-05-04T15:57:57Z | - |
dc.date.available | 2018-05-04T15:57:57Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | IMMUNOLOGY, 154 (3). p. 346-353 | - |
dc.identifier.issn | 0019-2805 | - |
dc.identifier.uri | http://hdl.handle.net/1942/25961 | - |
dc.description.abstract | The immune system evolved to protect organisms from invading patho-gens. A network of pro- and anti-inflammatory cell types equipped withspecial effector molecules guarantees efficient elimination of intruders likeviruses and bacteria. However, imbala nces can lead to an excessiveresponse of effector cells incurring autoimmune or allergic diseases. Aninterplay of genetic and environmental factors contributes to autoimmunediseases and recent studies provided evidence for an impact of dietaryhabits on the immune status and related disorders. Western societiesunderwent a change in lifestyle associated with changes in food consump-tion. Salt (sodium chloride) is one component prevalent in processed foodfrequently consume d in western countries. Here we summarize recentadvances in understanding the mechanisms behind the effects of sodiumchloride on immune cells like regula tory T cells (Tregs) and T helper(TH) 17 cells and its implication as a risk factor for several diseases. | - |
dc.description.sponsorship | M.K. was supported by the European Research Council (ERC)under the European Union’s Horizon 2020 research and inno-vation programme (640116), by an SALK-grant from the gov-ernmen t of Flanders, Belgium and by an Odysseus -grant of theResearch Foundation Flanders, Belgium (FWO). | - |
dc.language.iso | en | - |
dc.rights | (C) 2018 John Wiley & Sons Ltd, Immunology | - |
dc.subject.other | autoimmunity; diet; regulatory T cell; sodium chloride; Thelper (TH) 17 cells | - |
dc.title | The role of salt for immune cell function and disease | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 353 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 346 | - |
dc.identifier.volume | 154 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Kleinewietfeld, M (reprint author), Hasselt Univ, Ctr Inflammat Res, VIB Lab Translat Immunomodulat, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. markus.kleinewietfeld@vib-uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 640116 | - |
dc.identifier.doi | 10.1111/imm.12915 | - |
dc.identifier.isi | 000435272900003 | - |
item.validation | ecoom 2019 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | WILLEBRAND, Ralf & KLEINEWIETFELD, Markus (2018) The role of salt for immune cell function and disease. In: IMMUNOLOGY, 154 (3). p. 346-353. | - |
item.accessRights | Open Access | - |
item.contributor | WILLEBRAND, Ralf | - |
item.contributor | KLEINEWIETFELD, Markus | - |
crisitem.journal.issn | 0019-2805 | - |
crisitem.journal.eissn | 1365-2567 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Willebrand_et_al-2018-Immunology.pdf | Peer-reviewed author version | 319.7 kB | Adobe PDF | View/Open |
imm.12915.pdf Restricted Access | Published version | 282.05 kB | Adobe PDF | View/Open Request a copy |
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