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Title: | Twelve Weeks of Medium-Intensity Exercise Therapy Affects the Lipoprotein Profile of Multiple Sclerosis Patients. | Authors: | JORISSEN, Winde VANMIERLO, Tim WENS, Inez SOMERS, Veerle VAN WIJMEERSCH, Bart BOGIE, Jeroen Remaley, Alan OP 'T EIJNDE, Bert HENDRIKS, Jerome |
Issue Date: | 2018 | Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(1), p. 1-11 (Art N° 139) | Abstract: | Multiple sclerosis (MS) is an inflammatory auto-immune disease of the central nervous system (CNS). Serum glucose alterations and impaired glucose tolerance (IGT) are reported in MS patients, and are commonly associated with the development of cardio-metabolic co-morbidities. We previously found that a subgroup of MS patients shows alterations in their lipoprotein profile that are similar to a pre-cardiovascular risk profile. In addition, we showed that a high-intensity exercise training has a positive effect on IGT in MS patients. In this study, we hypothesize that exercise training positively influences the lipoprotein profile of MS patients. To this end, we performed a pilot study and determined the lipoprotein profile before (controls, n = 40; MS patients, n = 41) and after (n = 41 MS only) 12 weeks of medium-intensity continuous training (MIT, n = 21, ~60% of VO2max) or high-intensity interval training (HIT, n = 20, ~100–200% of VO2max) using nuclear magnetic resonance spectroscopy (NMR). Twelve weeks of MIT reduced intermediate-density lipoprotein particle count ((nmol/L); −43.4%; p < 0.01), low-density lipoprotein cholesterol (LDL-c (mg/dL); −7.6%; p < 0.05) and VLDL size ((nm); −6.6%; p < 0.05), whereas HIT did not influence the lipoprotein profile. These results show that MIT partially normalizes lipoprotein alterations in MS patients. Future studies including larger patient and control groups should determine whether MIT can reverse other lipoprotein levels and function and if these alterations are related to MS disease progression and the development of co-morbidities. | Notes: | Hendriks, JJA (reprint author), Hasselt Univ, Sch Life Sci, BIOMED, B-3590 Diepenbeek, Belgium, winde.jorissen@uhasselt.be; tim.vanmierlo@uhasselt.be; inez.wens@uhasselt.be; veerle.somers@uhasselt.be; bart.vanwijmeersch@uhasselt.be; jeroen.bogie@uhasselt.be; Alan.Remaley@nih.gov; bert.opteijnde@uhasselt.be; jerome.hendriks@uhasselt.be | Keywords: | multiple sclerosis; lipoproteins; cholesterol; training exercise | Document URI: | http://hdl.handle.net/1942/25968 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms19010193 | ISI #: | 000424407200190 | Rights: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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MDPI 2018.pdf | Published version | 507.53 kB | Adobe PDF | View/Open |
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