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http://hdl.handle.net/1942/2596
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DC Field | Value | Language |
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dc.contributor.author | VANDER BORGHT, Ann | - |
dc.contributor.author | De Keyser, F. | - |
dc.contributor.author | De Backer, M. | - |
dc.contributor.author | Malaise, M. | - |
dc.contributor.author | Baeten, D. | - |
dc.contributor.author | Van den Bosch, F. | - |
dc.contributor.author | Veys, E.M. | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.contributor.author | RAUS, Jef | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.date.accessioned | 2007-11-15T13:04:42Z | - |
dc.date.available | 2007-11-15T13:04:42Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | JOURNAL OF RHEUMATOLOGY, 29(3). p. 416-426 | - |
dc.identifier.issn | 0315-162X | - |
dc.identifier.uri | http://hdl.handle.net/1942/2596 | - |
dc.description.abstract | Objective. To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A (CSA) on TCR repertoire in a subgroup of these patients. Methods. Synovial tissue biopsies and paired blood samples were obtained from 12 patients with early RA at 2 time points. Seven patients were treated with CSA (Neoral-Sandimmun(R), 3 mg/kg/day) and 5 patients with placebo for 16 weeks. TCR V gene repertoires were analyzed by semiquantitative PCR-ELISA. CDR3 spectratyping and sequence analysis was used to compare TCR clonotype distributions. Results. TCR-specific mRNA was detected in all synovial tissue biopsies at the first sampling, but in only 8/12 biopsies 16 weeks later (4/7 CSA group, 4/5 placebo group). Overrepresented TCR BV genes were found in biopsies of 10/12 patients at the First time point, and in 7/12 patients after 16 weeks (3/7 CSA, 4/5 placebo). CDR3 sequence analysis revealed dynamic repertoire changes with only a few Persisting clonotypes in the synovial tissue of placebo controls. Persisting T cell clonotypes were more frequently found in the synovial tissue of CSA treated patients compared to the placebo group. Conclusion. These data suggest a dynamic process of T cell recruitment in the joints of RA patients. This process, possibly due to activation and subsequent infiltration of new T cell clones, apparently is influenced by CSA treatment. Synovial tissue T cells were no longer detected after 16 weeks' CSA treatment in 3 patients. In the other CSA treated patients, new T cell clones infiltrated, while other clones were persistently represented in the joints. These data may have important consequences for the design of T cell targeted therapies for PA. | - |
dc.language.iso | en | - |
dc.publisher | J RHEUMATOL PUBL CO | - |
dc.subject.other | rheumatoid arthritis; synovium; autoimmunity; T cell receptor repertoire; cyclosporin A | - |
dc.title | Dynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: Effects of treatment with cyclosporin A (Neoral (R)) | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 426 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 416 | - |
dc.identifier.volume | 29 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Limburgs Univ Ctr, Onderzoeksinst DWI, B-3590 Diepenbeek, Belgium. State Univ Ghent, Dept Rheumatol, Brussels, Belgium. Novartis Pharma, Brussels, Belgium. Univ Liege, Dept Rheumatol, Liege, Belgium.Stinissen, P, Limburgs Univ Ctr, Onderzoeksinst DWI, Univ Campus, B-3590 Diepenbeek, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | 000174214100003 | - |
dc.identifier.url | http://jrheum.com/abstracts/abstracts02/416.html | - |
item.accessRights | Closed Access | - |
item.fullcitation | VANDER BORGHT, Ann; De Keyser, F.; De Backer, M.; Malaise, M.; Baeten, D.; Van den Bosch, F.; Veys, E.M.; GEUSENS, Piet; RAUS, Jef & STINISSEN, Piet (2002) Dynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: Effects of treatment with cyclosporin A (Neoral (R)). In: JOURNAL OF RHEUMATOLOGY, 29(3). p. 416-426. | - |
item.fulltext | No Fulltext | - |
item.validation | ecoom 2003 | - |
item.contributor | VANDER BORGHT, Ann | - |
item.contributor | De Keyser, F. | - |
item.contributor | De Backer, M. | - |
item.contributor | Malaise, M. | - |
item.contributor | Baeten, D. | - |
item.contributor | Van den Bosch, F. | - |
item.contributor | Veys, E.M. | - |
item.contributor | GEUSENS, Piet | - |
item.contributor | RAUS, Jef | - |
item.contributor | STINISSEN, Piet | - |
crisitem.journal.issn | 0315-162X | - |
crisitem.journal.eissn | 1499-2752 | - |
Appears in Collections: | Research publications |
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