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Title: | Salt-responsive gut commensal modulates TH17 axis and disease | Authors: | Wilck, Nicola Matus, Mariana G. Kearney, Sean M. Olesen, Scott W. Forslund, Kristoffer Bartolomaeus, Hendrik Jörg, Stefanie Mähler, Anja Balogh, András Markó, Lajos Vvedenskaya, Olga Kleiner, Friedrich H. Tsvetkov, Dmitry Klug, Lars Costea, Paul I. Sunagawa, Shinichi Maier, Lisa Rakova, Natalia Schatz, Valentin Neubert, Patrick Frätzer, Christian Krannich, Alexander Gollasch, Maik Grohme, Diana A. Côrte-Real, Beatriz F. Gerlach, Roman G. Basic, Marijana Typas, Athanasios Wu, Chuan Titze, Jens M. Jantsch, Jonathan Boschmann, Michael Dechend, Ralf KLEINEWIETFELD, Markus Kempa, Stefan Bork, Peer Linker, Ralf A. Alm, Eric J. Müller, Dominik N. |
Issue Date: | 2017 | Source: | NATURE, 551(7682), p. 585-589 | Abstract: | A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension. Induction of TH17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension by modulating TH17 cells. In line with these findings, a moderate high-salt challenge in a pilot study in humans reduced intestinal survival of Lactobacillus spp., increased TH17 cells and increased blood pressure. Our results connect high salt intake to the gut–immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions. | Document URI: | http://hdl.handle.net/1942/25993 | ISSN: | 0028-0836 | e-ISSN: | 1476-4687 | DOI: | 10.1038/nature24628 | ISI #: | 000416520400034 | Rights: | © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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292981_7_high_res_merged_pdf_2872229_xwxgfx.pdf | Peer-reviewed author version | 3.07 MB | Adobe PDF | View/Open |
nature24628.pdf Restricted Access | Published version | 10.11 MB | Adobe PDF | View/Open Request a copy |
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