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Title: | GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: a MRS-TMS study | Authors: | Hermans, Lize Levin, Oron Maes, Celine van Ruitenbeek, Peter Heise, Kristin-Friederike Edden, Richard A.E. Puts, Nicolaas A.J. Peeters, Ronald King, Bradley R. MEESEN, Raf Leunissen, Inge Swinnen, Stephan P. CUYPERS, Koen |
Issue Date: | 2018 | Source: | NEUROBIOLOGY OF AGING, 65, p. 168-177 | Abstract: | Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63e74 years) and 28 young adults (19e34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/longinterval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABAĆ¾ levels. | Notes: | Cuypers, K (reprint author), Katholieke Univ Leuven, Grp Biomed Sci, Movement Control & Neuroplast Res Grp, Tervuursevest 101, B-3001 Leuven, Belgium, koen.cuypers@kuleuven.be | Keywords: | aging; gamma-aminobutyric acid (GABA); magnetic resonance spectroscopy (MRS); transcranial magnetic stimulation (TMS); intracortical inhibition; interhemispheric inhibition | Document URI: | http://hdl.handle.net/1942/25999 | ISSN: | 0197-4580 | e-ISSN: | 1558-1497 | DOI: | 10.1016/j.neurobiolaging.2018.01.023 | ISI #: | 000428233700017 | Rights: | (C) 2018 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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