Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26085
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dc.contributor.authorVRIENS, Annette-
dc.contributor.authorPROVOST, Eline-
dc.contributor.authorSAENEN, Nelly-
dc.contributor.authorDE BOEVER, Patrick-
dc.contributor.authorVRIJENS, Karen-
dc.contributor.authorDe Wever, Oliver-
dc.contributor.authorPLUSQUIN, Michelle-
dc.contributor.authorNAWROT, Tim-
dc.date.accessioned2018-06-19T13:25:02Z-
dc.date.available2018-06-19T13:25:02Z-
dc.date.issued2018-
dc.identifier.citationScientific Reports, 8(1) (Art N° 8209)-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/1942/26085-
dc.description.abstractAn imbalance between energy uptake and energy expenditure is the most important reason for increasing trends in obesity starting from early in life. Extracellular miRNAs are expressed in all bodily fluids and their expression is influenced by a broad range of stimuli. We examined whether screen time, physical activity and BMI are associated with children's salivary extracellular miR-222 and miR-146a expression. In 80 children the extracellular fraction of saliva was obtained by means of differential centrifugation and ultracentrifugation. Expression levels of miR-222 and miR-146a were profiled by qPCR. We studied the association between children's salivary extracellular miRNA expression and screen time, physical activity and BMI using mixed models, while accounting for potential confounders. We found that higher screen time was positively associated with salivary extracellular miR-222 and miR-146a levels. On average, one hour more screen time use per week was associated with a 3.44% higher miR-222 (95% CI: 1.34 to 5.58; p = 0.002) and 1.84% higher miR-146a (95% CI: -0.04 to 3.75; p = 0.055) level in saliva. BMI and physical activity of the child were not significantly associated with either miR-222 or miR-146a. A sedentary behaviour, represented by screen time use in children, is associated with discernible changes in salivary expression of miR-146a and or miR-222. These miRNA targets may emerge attractive candidates to explore the role of these exposures in developmental processes of children's health.-
dc.description.sponsorshipThe authors thank Michal Kicinski for his contributions during the COGNAC study. The COGNAC study is supported by grants from the European Research Council (ERC-2012-StG310898) and the Flemish Scientific Fund (FWO, 1516112 N/G.0873.11.N.10). AV has a PhD fellowship from Bijzonder Onderzoeksfonds (BOF) Hasselt University. KV has a postdoctoral fellowship of the Research Foundation - Flanders (FWO), 12D7718N. Datasets generated during the study can be obtained through the corresponding author upon reasonable request.-
dc.language.isoen-
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © Te Author(s) 2018-
dc.titleChildren's screen time alters the expression of saliva extracellular miR-222 and miR-146a.-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume8-
local.bibliographicCitation.jcatA1-
dc.description.notesNawrot, TS (reprint author), Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium. tim.nawrot@uhasselt.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr8209-
dc.identifier.doi10.1038/s41598-018-26351-2-
dc.identifier.isi000433289600025-
item.contributorVRIENS, Annette-
item.contributorPROVOST, Eline-
item.contributorSAENEN, Nelly-
item.contributorDE BOEVER, Patrick-
item.contributorVRIJENS, Karen-
item.contributorDe Wever, Oliver-
item.contributorPLUSQUIN, Michelle-
item.contributorNAWROT, Tim-
item.fulltextWith Fulltext-
item.validationecoom 2019-
item.fullcitationVRIENS, Annette; PROVOST, Eline; SAENEN, Nelly; DE BOEVER, Patrick; VRIJENS, Karen; De Wever, Oliver; PLUSQUIN, Michelle & NAWROT, Tim (2018) Children's screen time alters the expression of saliva extracellular miR-222 and miR-146a.. In: Scientific Reports, 8(1) (Art N° 8209).-
item.accessRightsOpen Access-
crisitem.journal.issn2045-2322-
crisitem.journal.eissn2045-2322-
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