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http://hdl.handle.net/1942/26240
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DC Field | Value | Language |
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dc.contributor.author | Han, Sileny N. | - |
dc.contributor.author | Amant, Frederic | - |
dc.contributor.author | Michielsen, Katrijn | - |
dc.contributor.author | De Keyzer, Frederik | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | Van Calsteren, Kristel | - |
dc.contributor.author | Dresen, Raphaela C. | - |
dc.contributor.author | Gziri, Mina Mhallem | - |
dc.contributor.author | Vandecaveye, Vincent | - |
dc.date.accessioned | 2018-06-29T08:13:20Z | - |
dc.date.available | 2018-06-29T08:13:20Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | EUROPEAN RADIOLOGY, 28(5), p. 1862-1874 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26240 | - |
dc.description.abstract | To evaluate the feasibility of whole-body diffusion-weighted MRI (WB-DWI/MRI) for detecting primary tumour, nodal and distant metastases in pregnant women with cancer. Twenty pregnant patients underwent WB-DWI/MRI in additional to conventional imaging. Reproducibility of WB-DWI/MRI between two readers was evaluated using Cohen's kappa statistics and accuracy was compared to conventional imaging for assessing primary tumour site, nodal and visceral metastases. Both WB-DWI/MRI readers showed good-very good agreement for lesion detection (primary lesions: kappa=1; lymph nodes: kappa=0.89; distant metastases: kappa=0.61). Eight (40 %) patients were upstaged after WB-DWI/MRI. For nodal metastases, WB-DWI/MRI showed 100 % (95 % CI: 83.2-100) sensitivity for both readers with specificity of 99.4 % (96.9-100) and 100 % (80.5-100) for readers 1 and 2, respectively. For distant metastases, WB-DWI/MRI showed 66.7 % (9.4-99.2) and 100 % (29.2-100) sensitivity and specificity of 94.1 % (71.3-99.9) and 100 % (80.5-100) for readers 1 and 2, respectively. Conventional imaging showed sensitivity of 50 % (27.2-72.8) and 33.3 % (0.8-90.6); specificity of 100 % (98-100) and 100 % (80.5-100), for nodal and distant metastases respectively. WB-DWI/MRI is feasible for single-step non-invasive staging of cancer during pregnancy with additional value for conventional imaging procedures. aEuro cent In our study, WB-DWI/MRI was more accurate than conventional imaging during pregnancy. aEuro cent WB-DWI/MRI improves diagnostic assessment of patients with cancer during pregnancy. aEuro cent Accurate imaging and oncologic staging improves treatment and outcome. | - |
dc.description.sponsorship | This study has received funding by Research Fund Flanders (F.W.O.). Supported by grants from the Belgian Cancer Plan (Ministry of Health), Stichting tegen Kanker and the CRADLE project supported by the European Research Council. | - |
dc.language.iso | en | - |
dc.rights | (C) European Society of Radiology 2017 | - |
dc.subject.other | magnetic resonance imaging; diffusion magnetic resonance imaging; cancer; pregnancy; staging | - |
dc.title | Feasibility of whole-body diffusion-weighted MRI for detection of primary tumour, nodal and distant metastases in women with cancer during pregnancy: a pilot study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1874 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1862 | - |
dc.identifier.volume | 28 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Amant, F (reprint author), Univ Hosp Leuven, Dept Obstet, Herestr 49, B-3000 Leuven, Belgium, frederic.amant@uzleuven.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s00330-017-5126-z | - |
dc.identifier.isi | 000429104200009 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Han, Sileny N.; Amant, Frederic; Michielsen, Katrijn; De Keyzer, Frederik; FIEUWS, Steffen; Van Calsteren, Kristel; Dresen, Raphaela C.; Gziri, Mina Mhallem & Vandecaveye, Vincent (2018) Feasibility of whole-body diffusion-weighted MRI for detection of primary tumour, nodal and distant metastases in women with cancer during pregnancy: a pilot study. In: EUROPEAN RADIOLOGY, 28(5), p. 1862-1874. | - |
item.contributor | Han, Sileny N. | - |
item.contributor | Amant, Frederic | - |
item.contributor | Michielsen, Katrijn | - |
item.contributor | De Keyzer, Frederik | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | Van Calsteren, Kristel | - |
item.contributor | Dresen, Raphaela C. | - |
item.contributor | Gziri, Mina Mhallem | - |
item.contributor | Vandecaveye, Vincent | - |
item.validation | ecoom 2019 | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0938-7994 | - |
crisitem.journal.eissn | 1432-1084 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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han 1.pdf Restricted Access | Published version | 7.22 MB | Adobe PDF | View/Open Request a copy |
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