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Title: Long-term clinical outcomes of a crystalline sirolimus-eluting coronary stent with a fully bioabsorbable polymer coating: five-year outcomes from the DESSOLVE I and II trials
Authors: Wijns, William
VROLIX, Mathias 
Verheye, Stefan
Schoors, Danny
Slagboom, Ton
Gosselink, Marcel
BENIT, Edouard 
Kandzari, David
Donohoe, Dennis
Ormiston, John
Issue Date: 2018
Source: EUROINTERVENTION, 13(18), p. E2147-E2151
Abstract: Aims: The aim of this study was to evaluate the five-year clinical results of a sirolimus-eluting stent (MiStent SES) with a bioabsorbable coating designed for sustained drug delivery during and after rapid polymer dissolution. Methods and results: The five-year results from the DESSOLVE I and II trials including major adverse cardiac events (MACE), target lesion failure (TLF), target vessel failure (TVF), and stent thrombosis (ST) at five-year follow-up are reported. In DESSOLVE I, 10.3% of patients receiving the MiStent SES (3/29) had a MACE event up to five years without TLF. In DESSOLVE II, 15.1% of patients in the MiStent group (18/119) had a five-year MACE event compared to 22.0% of patients in the Endeavor group (p= 0.295). TLF was 9.2% in the MiStent group and 8.5% in the Endeavor group (p= 1.00). TVF was 10.1% for MiStent versus 15.3% for Endeavor (p= 0.331). Up to five-year follow-up, the MiStent SES has continued to demonstrate low rates of TLR across DESSOLVE I (0.0%) and DESSOLVE II (3.4%). No ST was reported with the MiStent up to five years in the DESSOLVE I trial. In DESSOLVE II, definite or probable ST was 0.0% with MiStent and 1.7% with Endeavor up to five years. Conclusions: The MiStent SES demonstrated long-term safety and effectiveness with low rates of fiveyear MACE, TLF, and TVF across these two clinical trials.
Notes: Wijns, W (reprint author), Natl Univ Ireland Galway, Lambe Inst Translat Med, Floor 2,Univ Rd, Galway H91 TK33, Ireland.
Keywords: clinical research; clinical trials; drug-eluting stent; multiple vessel disease; single vessel disease
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ISSN: 1774-024X
e-ISSN: 1969-6213
DOI: 10.4244/EIJ-D-17-00230
ISI #: 000430649300013
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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