Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26251
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dc.contributor.authorPraet, Jelle-
dc.contributor.authorManyakov, Nikolay V.-
dc.contributor.authorMUCHENE, Leacky-
dc.contributor.authorMai, Zhenhua-
dc.contributor.authorTerzopoulos, Vasilis-
dc.contributor.authorde Backer, Steve-
dc.contributor.authorTorremans, An-
dc.contributor.authorGuns, Pieter-Jan-
dc.contributor.authorVan De Casteele, Tom-
dc.contributor.authorBottelbergs, Astrid-
dc.contributor.authorVan Broeck, Bianca-
dc.contributor.authorSijbers, Jan-
dc.contributor.authorSmeets, Dirk-
dc.contributor.authorSHKEDY, Ziv-
dc.contributor.authorBIJNENS, Luc-
dc.contributor.authorPemberton, Darrel J.-
dc.contributor.authorSchmidt, Mark E.-
dc.contributor.authorVan der Linden, Annemie-
dc.contributor.authorVerhoye, Marleen-
dc.date.accessioned2018-06-29T09:40:30Z-
dc.date.available2018-06-29T09:40:30Z-
dc.date.issued2018-
dc.identifier.citationALZHEIMERS RESEARCH & THERAPY, 10 (Art N° 1)-
dc.identifier.issn1758-9193-
dc.identifier.urihttp://hdl.handle.net/1942/26251-
dc.description.abstractBackground: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using diffusion kurtosis imaging (DKI) as a tool for the early detection of microstructural changes in the brain due to amyloid-beta (A beta) plaque deposition. Methods: We longitudinally acquired DKI data of wild-type (WT) and APP/PS1 mice at 2, 4, 6 and 8 months of age, after which these mice were sacrificed for histological examination. Three additional cohorts of mice were also included at 2, 4 and 6 months of age to allow voxel-based co-registration between diffusion tensor and diffusion kurtosis metrics and immunohistochemistry. Results: Changes were observed in diffusion tensor (DT) and diffusion kurtosis (DK) metrics in many of the 23 regions of interest that were analysed. Mean and axial kurtosis were greatly increased owing to A beta-induced pathological changes in the motor cortex of APP/PS1 mice at 4, 6 and 8 months of age. Additionally, fractional anisotropy (FA) was decreased in APP/PS1 mice at these respective ages. Linear discriminant analysis of the motor cortex data indicated that combining diffusion tensor and diffusion kurtosis metrics permits improved separation of WT from APP/PS1 mice compared with either diffusion tensor or diffusion kurtosis metrics alone. We observed that mean kurtosis and FA are the critical metrics for a correct genotype classification. Furthermore, using a newly developed platform to co-register the in vivo diffusion-weighted magnetic resonance imaging with multiple 3D histological stacks, we found high correlations between DK metrics and anti-A beta (clone 4G8) antibody, glial fibrillary acidic protein, ionised calcium-binding adapter molecule 1 and myelin basic protein immunohistochemistry. Finally, we observed reduced FA in the septal nuclei of APP/PS1 mice at all ages investigated. The latter was at least partially also observed by voxel-based statistical parametric mapping, which showed significantly reduced FA in the septal nuclei, as well as in the corpus callosum, of 8-month-old APP/PS1 mice compared with WT mice. Conclusions: Our results indicate that DKI metrics hold tremendous potential for the early detection and longitudinal follow-up of A beta-induced pathology.-
dc.description.sponsorshipThis research was supported in part by funding received from the European Union under grant agreement number 612360 (BRAINPATH) within the Marie Curie Actions-Industry-Academia Partnerships and Pathways (IAPP) program (to AVdL), by the Hercules stichting AUHA/012 financing MRI research infrastructure, and in part by a research and development grant from the Flemish Agency for Innovation by Science and Technology (IWT) under grant agreement number 120178 and Fund for Scientific Research Flanders (FWO) (AVdL- G057615N).-
dc.language.isoen-
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.-
dc.subject.otherMagnetic resonance imaging; Diffusion tensor imaging; Diffusion kurtosis imaging; Alzheimer's disease; APP/PS1-
dc.titleDiffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-beta-induced pathology-
dc.typeJournal Contribution-
dc.identifier.volume10-
local.bibliographicCitation.jcatA1-
dc.description.notesVerhoye, M (reprint author), Univ Antwerp, Bioimaging Lab, Campus Drie Eiken CDE Uc1-14,Univ Pl 1, B-2610 Antwerp, Belgium, marleen.verhoye@uantwerpen.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr1-
dc.identifier.doi10.1186/s13195-017-0329-8-
dc.identifier.isi000425762700001-
item.accessRightsOpen Access-
item.fullcitationPraet, Jelle; Manyakov, Nikolay V.; MUCHENE, Leacky; Mai, Zhenhua; Terzopoulos, Vasilis; de Backer, Steve; Torremans, An; Guns, Pieter-Jan; Van De Casteele, Tom; Bottelbergs, Astrid; Van Broeck, Bianca; Sijbers, Jan; Smeets, Dirk; SHKEDY, Ziv; BIJNENS, Luc; Pemberton, Darrel J.; Schmidt, Mark E.; Van der Linden, Annemie & Verhoye, Marleen (2018) Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-beta-induced pathology. In: ALZHEIMERS RESEARCH & THERAPY, 10 (Art N° 1).-
item.contributorPraet, Jelle-
item.contributorManyakov, Nikolay V.-
item.contributorMUCHENE, Leacky-
item.contributorMai, Zhenhua-
item.contributorTerzopoulos, Vasilis-
item.contributorde Backer, Steve-
item.contributorTorremans, An-
item.contributorGuns, Pieter-Jan-
item.contributorVan De Casteele, Tom-
item.contributorBottelbergs, Astrid-
item.contributorVan Broeck, Bianca-
item.contributorSijbers, Jan-
item.contributorSmeets, Dirk-
item.contributorSHKEDY, Ziv-
item.contributorBIJNENS, Luc-
item.contributorPemberton, Darrel J.-
item.contributorSchmidt, Mark E.-
item.contributorVan der Linden, Annemie-
item.contributorVerhoye, Marleen-
item.fulltextWith Fulltext-
item.validationecoom 2019-
crisitem.journal.eissn1758-9193-
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