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Title: | DNA Methylome Marks of Exposure to Particulate Matter at Three Time Points in Early Life | Authors: | PLUSQUIN, Michelle Chadeau-Hyam, Marc Ghantous, Akram ALFANO, Rossella Bustamante, Mariona Chatzi, Leda Cuenin, Cyrille Gulliver, John Herceg, Zdenko Kogevinas, Manolis NAWROT, Tim Pizzi, Costanza Porta, Daniela Relton, Caroline L. Richiardi, Lorenzo Robinson, Oliver Sunyer, Jordi Vermeulen, Roel VRIENS, Annette Vrijheid, Martine Henderson, John Vineis, Paolo |
Issue Date: | 2018 | Publisher: | AMER CHEMICAL SOC | Source: | ENVIRONMENTAL SCIENCE & TECHNOLOGY, 52(9), p. 5427-5437 | Abstract: | Maternal exposure to airborne particulate matter (PM) has been associated with restricted fetal growth and reduced birthweight. Here, we performed methylome-wide analyses of cord and children's blood DNA in relation to residential exposure to PM smaller than 10 mu m (PM10). This study included participants of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC, cord blood, n = 780; blood at age 7, n = 757 and age 15-17, n = 850) and the EXPosOMICS birth cohort consortium including cord blood from ENVIRON-AGE (n = 197), INMA (n = 84), Piccolipiu (n = 99) and Rhea (n = 75). We could not identify significant CpG sites, by meta-analyzing associations between maternal PM10 exposure during pregnancy and DNA methlation in cord blood, nor by studying DNA methylation and concordant annual exposure at 7 and 15-17 years. The CpG cg21785536 was inversly associated with PM10 exposure using a longitudinal model integrating the three studied age groups (-1.2% per 10 mu g/m(3); raw p-value = 3.82 X 10(-8)). Pathway analyses on the corresponding genes of the 100 strongest associated CpG sites of the longitudinal model revealed enriched pathways relating to the GABAergic synapse, p53 signaling and NOTCH1. We provided evidence that residential PM10 exposure in early life affects methylation of the CpG cg21785536 located on the EGF Domain Specific O-Linked N-Acetylglucosamine Transferase gene. | Notes: | [Plusquin, Michelle; Alfano, Rossella; Nawrot, Tim S.; Vriens, Annette; Vineis, Paolo] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Plusquin, Michelle; Chadeau-Hyam, Marc; Alfano, Rossella; Robinson, Oliver; Vineis, Paolo] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England. [Plusquin, Michelle; Chadeau-Hyam, Marc; Alfano, Rossella; Gulliver, John; Robinson, Oliver; Vermeulen, Roel] Imperial Coll London, Med Res Council Hlth Protect Agcy Ctr Environm &, London, England. [Chadeau-Hyam, Marc; Vermeulen, Roel] Univ Utrecht, Div Environm Epidemiol, IRAS, Utrecht, Netherlands. [Ghantous, Akram; Cuenin, Cyrille; Herceg, Zdenko] IARC, 150 Cours Albert Thomas, F-69008 Lyon, France. [Bustamante, Mariona] Barcelona Inst Sci & Technol, CRG, Barcelona, Spain. [Bustamante, Mariona; Kogevinas, Manolis; Sunyer, Jordi; Vrijheid, Martine] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain. [Bustamante, Mariona; Kogevinas, Manolis; Sunyer, Jordi; Vrijheid, Martine] Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain. [Bustamante, Mariona; Kogevinas, Manolis; Vrijheid, Martine] UPF, Barcelona, Catalonia, Spain. [Chatzi, Leda] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA. [Chatzi, Leda] Univ Crete, Dept Social Med, Iraklion, Crete, Greece. [Kogevinas, Manolis; Sunyer, Jordi] Hosp del Mar, Med Res Inst, IMIM, Barcelona, Spain. [Nawrot, Tim S.] Leuven Univ, Environm & Hlth Unit, Leuven, Belgium. [Pizzi, Costanza; Richiardi, Lorenzo] Univ Turin, Dept Med Sci, Canc Epidemiol Unit CERMS, Turin, Italy. [Pizzi, Costanza; Richiardi, Lorenzo] CPO Piemonte, Turin, Italy. [Porta, Daniela] Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy. [Relton, Caroline L.] Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, MRC Integrat Epidemiol Unit, Bristol, Avon, England. [Henderson, John] Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, Bristol, Avon, England. [Vineis, Paolo] Italian Inst Genom Med, IIGM, Turin, Italy. | Document URI: | http://hdl.handle.net/1942/26261 | ISSN: | 0013-936X | e-ISSN: | 1520-5851 | DOI: | 10.1021/acs.est.7b06447 | ISI #: | 000431466500042 | Rights: | Copyright © 2018 American Chemical Society | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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plusquin 1.pdf Restricted Access | Published version | 2.58 MB | Adobe PDF | View/Open Request a copy |
DNA.pdf | Peer-reviewed author version | 1.91 MB | Adobe PDF | View/Open |
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