Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/26270
Title: | Dimethyl fumarate induces a persistent change in the composition of the innate and adaptive immune system in multiple sclerosis patients | Authors: | MONTES DIAZ, Gwendoline FRAUSSEN, Judith VAN WIJMEERSCH, Bart Hupperts, R. SOMERS, Veerle |
Issue Date: | 2018 | Source: | SCIENTIFIC REPORTS, 8 (Art N° 8194) | Abstract: | The effects of dimethyl fumarate (DMF) on the immune system in multiple sclerosis (MS) are not completely elucidated. In this study, an extensive immunophenotypic analysis of innate and adaptive immune cells of DMF-treated MS patients was performed. Peripheral blood immune cell phenotypes were determined using flow cytometry in a follow-up study of 12 MS patients before, after 3 and 12 months of DMF treatment and a cross-sectional study of 25 untreated and 64 DMF-treated MS patients. Direct effects of DMF on B cells were analyzed in vitro. After 12 months of DMF treatment, percentages of monocytes, natural killer cells, naive T and B cells and transitional B cells increased. Percentages of (effector) memory T cells, (non) class-switched memory B cells and double negative B cells decreased together with CD4(+) T cells expressing interferon-gamma (IFN-gamma), granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL-17). DMF treatment was fully effective as of 6 months and directly induced apoptosis and decreased expression of costimulatory CD40, antigen presentation molecule MHCII and B cell activating factor receptor (BAFFR) on B cells. DMF induced a persistent change of the immune system of MS patients, directly induced apoptosis and reduced expression of functional markers on B cells. | Notes: | Somers, V (reprint author), Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. veerle.somers@uhasselt.be | Document URI: | http://hdl.handle.net/1942/26270 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-26519-w | ISI #: | 000433289600010 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
diaz 1.pdf | Published version | 2.83 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
16
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
54
checked on Oct 12, 2024
Page view(s)
68
checked on Sep 7, 2022
Download(s)
104
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.