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Title: | Office and Home Blood Pressures as Determinants of Electrocardiographic Left Ventricular Hypertrophy Among Black Nigerians Compared With White Flemish | Authors: | Odili, Augustine N. Thijs, Lutgarde Yang, Wen-Yi Ogedengbe, John O. Nwegbu, Maxwell M. Jacobs, Lotte Wei, Fang-Fei Feng, Ying-Mei Zhang, Zhen-Yu Kuznetsova, Tatiana NAWROT, Tim Staessen, Jan A. |
Issue Date: | 2017 | Publisher: | OXFORD UNIV PRESS | Source: | AMERICAN JOURNAL OF HYPERTENSION, 30(11), p. 1083-1092 | Abstract: | BACKGROUND The association of electrocardiographic left ventricular hypertrophy (ECG-LVH) with blood pressure (BP) in Blacks living in sub-Saharan Africa remains poorly documented. METHODS In 225 Black Nigerians and 729 White Flemish, we analyzed QRS voltages and voltage-duration products and 12 criteria diagnostic of ECG-LVH in relation to office BP (mean of 5 consecutive readings) and home BP (duplicate morning and evening readings averaged over 1 week). RESULTS In multivariable analyses, QRS voltage and voltage-duration indexes were generally higher in Blacks than Whites. By using any of 12 criteria, ECG-LVH was more prevalent among Black than White men (54.4% vs. 36.0%) with no ethnic difference among women (17.1%). Precordial voltages and voltage-duration products increased with office and home systolic BP (SBP), and increases were up to 3-fold steeper in Blacks. In Blacks vs. Whites, increases in the Sokolow-Lyon voltage associated with a 10-mm Hg higher SBP were 0.18 mV (95% confidence interval [CI], 0.09-0.26) vs. 0.06 mV (0.02-0.09) and 0.17 mV (0.07-0.28) vs. 0.11 mV (CI, 0.07-0.15) for office and home BP, respectively, with a significant ethnic gradient (P < 0.05). The risk of ECG-LVH increased more with office and home BP in Blacks than Whites. CONCLUSIONS Associations of ECG voltages and voltage-duration products and risk of ECG-LVH with BP are steeper in Black Nigerians compared with a White reference population. In resource-poor settings of sub-Saharan Africa, the ECG in combination with office and home BP is an essential instrument in risk stratification across the entire BP range. | Notes: | [Odili, Augustine N.; Thijs, Lutgarde; Yang, Wen-Yi; Jacobs, Lotte; Wei, Fang-Fei; Zhang, Zhen-Yu; Kuznetsova, Tatiana; Staessen, Jan A.] Univ Leuven, Studies Coordinating Ctr, Res Unit Hypertens & Cardiovasc Epidemiol, KU Leuven Dept Cardiovasc Sci, Leuven, Belgium. [Odili, Augustine N.; Ogedengbe, John O.] Univ Abuja, Fac Clin Sci, Coll Hlth Sci, Dept Internal Med, Abuja, Nigeria. [Ogedengbe, John O.] Univ Abuja, Dept Human Physiol, Fac Basic Med Sci, Coll Hlth Sci, Abuja, Nigeria. [Nwegbu, Maxwell M.] Univ Abuja, Dept Chem Pathol, Fac Basic Clin Sci, Coll Hlth Sci, Abuja, Nigeria. [Feng, Ying-Mei] Capital Med Univ, Lu He Hosp, Beijing Key Lab Diabet Prevent & Res, Dept Endocrinol, Beijing, Peoples R China. [Nawrot, Tim S.] Univ Hasselt, Ctr Environm Sci, Diepenbeek, Belgium. [Staessen, Jan A.] Maastricht Univ, R&D Grp VitaK, Maastricht, Netherlands. | Keywords: | blood pressure; electrocardiography; ethnicity; home blood pressure; hypertension; left ventricular hypertrophy; population science; risk stratification; special populations;blood pressure; electrocardiography; ethnicity; home blood pressure; hypertension; left ventricular hypertrophy; population science; risk stratification; special populations | Document URI: | http://hdl.handle.net/1942/26291 | ISSN: | 0895-7061 | e-ISSN: | 1941-7225 | DOI: | 10.1093/ajh/hpx114 | ISI #: | 000414354700010 | Rights: | © The Author 2017. Published by Oxford University Press on behalf of the American Journal of Hypertension, Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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