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http://hdl.handle.net/1942/26293
Title: | Endovascular shedding markers in patients with heart failure with reduced ejection fraction: Results from a single-center exploratory study | Authors: | NIJST, Petra COPS, Jirka MARTENS, Pieter SWENNEN, Quirine DUPONT, Matthias Tang, Wai Hong W. MULLENS, Wilfried |
Issue Date: | 2018 | Source: | MICROCIRCULATION, 25(2) (Art N° e12432) | Abstract: | Background: Endothelial glycocalyx degradation has been associated with multiple pathophysiological processes in cardiovascular disease. Aims: To explore the role of glycocalyx shedding markers in pathophysiology of HFrEF. Methods: In 123 HFrEF patients, the concentration, prognostic value, and association of glycocalyx shedding markers with other disease processes were investigated. Results: Median HA levels and syndecan-1 levels in HFrEF patients were, respectively, 29.4 (10.7;61.6) ng/mL and 48.5 (33.6;80.8) ng/mL. Overall, HA-levels were significantly higher in HFrEF patients compared to healthy subjects, but only 31% of HFrEF patients had HA-levels above the cutoff of normal. There was no significant difference among HFrEF patients and healthy subjects regarding syndecan-1 levels. HFrEF patients with elevated HA-levels had a significantly worse outcome (log rank = 0.01) which remained significant after correction for established risk factors (HR 2.53 (1.13-5.69); P = .024). There was no significant relation between levels of shedding markers and neurohumoral activation (PRA, serum aldosterone, NT-proBNP), myocardial injury (HS-trop), inflammation (CRP), or other baseline characteristics. Conclusions: The glycocalyx shedding marker HA is significantly elevated in a subgroup of HFrEF patients and an independent predictor for worse clinical outcome. Glycocalyx shedding might be an additional factor in the pathophysiology of HF which warrants further investigation. | Notes: | Nijst, P (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Genk, Belgium. nijst.petra@gmail.com | Keywords: | glycocalyx; hyaluronic acid; outcome; syndecan-1; systolic heart failure | Document URI: | http://hdl.handle.net/1942/26293 | ISSN: | 1073-9688 | e-ISSN: | 1549-8719 | DOI: | 10.1111/micc.12432 | ISI #: | 000424813900006 | Rights: | © 2017 John Wiley & Sons Ltd | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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Nijst_et_al-2018-Microcirculation.pdf Restricted Access | Published version | 594.68 kB | Adobe PDF | View/Open Request a copy |
nijst2017.pdf | Peer-reviewed author version | 380.76 kB | Adobe PDF | View/Open |
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