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Title: | The interval approach: an adaptation of the liver-first approach to treat synchronous liver metastases from rectal cancer | Authors: | D'Hondt, Mathieu Lucidi, Valerio Vermeiren, Koen Van Den Bossche, Bert Donckier, Vincent SERGEANT, Gregory |
Issue Date: | 2017 | Publisher: | BIOMED CENTRAL LTD | Source: | WORLD JOURNAL OF SURGICAL ONCOLOGY, 15 (Art N° 54) | Abstract: | Background: The waiting interval after chemoradiotherapy (CRT) is an interesting therapeutic window to treat patients with synchronous liver metastases (SLM) from rectal cancer. Methods: A retrospective analysis was performed of 18 consecutive patients (M/F 10/8, age (range) 60 (51-75) years) from five institutions who underwent liver resection of SLM during the waiting interval after CRT for rectal adenocarcinoma. Results: All patients underwent interval liver surgery for a median (range) of 4 (2-14) liver metastases. Metastases involved a median (range) of 4 (1-7) liver segments. Median (range) time between end of CRT and liver surgery was 22 (6-45) days. Laparoscopic liver surgery was performed in 12 (67%) patients. No severe complications (Clavien-Dindo >= 3b) occurred after liver surgery. Median (range) length of hospital stay after liver surgery was 5 (1-10) days. All patients subsequently underwent rectal resection at a median (range) of 10 (8-13) weeks after end of CRT. Median (IQR) time-to-progression after liver surgery was 4.2 (2.8-9.2) months. Conclusions: The waiting interval after neoadjuvant CRT is a valuable option to treat SLM from rectal cancer. More data are necessary to confirm its oncological efficacy. | Notes: | [D'Hondt, Mathieu] AZ Groeninge, Dept Abdominal Surg, Kortrijk, Belgium. [Lucidi, Valerio; Donckier, Vincent] Hop Erasme, Dept Abdominal Surg, Brussels, Belgium. [Vermeiren, Koen] AZ Imelda, Dept Abdominal Surg, Bonheiden, Belgium. [Van Den Bossche, Bert] Algemeen Stedelijk Ziekenhuis, Dept Abdominal Surg, Aalst, Belgium. [Sergeant, Gregory] Jessa Ziekenhuis, Dept Abdominal Surg, Salvatorstr 20, B-3500 Hasselt, Belgium. [Sergeant, Gregory] UHasselt, Fac Med & Life Sci, Hasselt, Belgium. | Keywords: | synchronous liver metastasis; rectal cancer; liver resection; simultaneous approach; delayed approach; interval approach;Synchronous liver metastasis; Rectal cancer; Liver resection; Simultaneous approach; Delayed approach; Interval approach | Document URI: | http://hdl.handle.net/1942/26378 | ISSN: | 1477-7819 | e-ISSN: | 1477-7819 | DOI: | 10.1186/s12957-017-1123-6 | ISI #: | 000396766000001 | Rights: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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