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http://hdl.handle.net/1942/26432
Title: | Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis | Authors: | Majdinasab, Nastaran Motl, Robert W. Mokhtarzade, Motahare Zimmer, Philipp Ranjbar, Rouholah KEYTSMAN, Charly Cullen, Tom Negaresh, Raoof Baker, Julien S. |
Issue Date: | 2018 | Source: | COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE, 31, p. 295-301 | Abstract: | Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise. Results: Levels of IL-10 and TNF-alpha in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-alpha levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups. Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance. (C) 2018 Elsevier Ltd. All rights reserved. | Notes: | Mokhtarzade, M (reprint author), Ahvaz Jundishapur Univ Med Sci, Sch Med, Musculoskeletal Rehabil Res Ctr, Ahwaz, Iran. mz.mokhtarzade@yahoo.com | Keywords: | multiple sclerosis; cytokines; inflammation; adipokines; aerobic interval exercise | Document URI: | http://hdl.handle.net/1942/26432 | ISSN: | 1744-3881 | e-ISSN: | 1873-6947 | DOI: | 10.1016/j.ctcp.2018.03.004 | ISI #: | 000432520800044 | Rights: | (C) 2018 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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majdinasab2018.pdf | Peer-reviewed author version | 808.01 kB | Adobe PDF | View/Open |
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