Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/26461
Title: | Particle Size Control during Ultrasonic Cooling Crystallization of Paracetamol | Authors: | GIELEN, Bjorn Claes, Thomas Janssens, Jonas JORDENS, Jeroen Thomassen, Leen C. J. Van Gerven, Tom BRAEKEN, Leen |
Issue Date: | 2017 | Source: | CHEMICAL ENGINEERING & TECHNOLOGY, 40(7), p. 1300-1308 | Abstract: | The effect of ultrasound on the crystal size during cooling crystallization of paracetamol was investigated. Sonication was enabled in three distinct stages to define the operating guidelines for crystal size control. In addition, it was identified whether size reduction results from a higher amount of nuclei upon primary nucleation or from enhanced secondary nucleation. The results show that tuning of the ultrasonic power density and exposure time after nucleation results in crystal sizes between 70 and 140 mm. In contrast, the use of ultrasound before nucleation does not affect the size, indicating enhanced secondary nucleation as the main mechanism. Finally, sonication after complete desupersaturation reduces the crystal size by about 30 mm but causes surface erosion. | Keywords: | crystallization; particle size; process control; ultrasound | Document URI: | http://hdl.handle.net/1942/26461 | ISSN: | 0930-7516 | e-ISSN: | 1521-4125 | DOI: | 10.1002/ceat.201600647 | ISI #: | 000405290700014 | Rights: | (C) 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
download.pdf | Peer-reviewed author version | 1.44 MB | Adobe PDF | View/Open |
ceat.201600647.pdf Restricted Access | Published version | 650.87 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
8
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
24
checked on Oct 4, 2024
Page view(s)
74
checked on Sep 7, 2022
Download(s)
140
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.