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Title: | Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic | Authors: | Vandenplas, Yvan Ludwig, Thomas Bouritius, Hetty ALLIET, Philippe Forde, Derek Peeters, Stefaan Huet, Frederic Hourihane, Jonathan |
Issue Date: | 2017 | Source: | ACTA PAEDIATRICA, 106(7), p. 1150-1158 | Abstract: | Aim: We examined the effects on gastrointestinal (GI) tolerance of a novel infant formula that combined specific fermented formula (FERM) with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS), with a 9: 1 ratio and concentration of 0.8 g/100 mL. Methods: This prospective, double-blind, randomised, controlled trial comprised 432 healthy, term infants aged 0-28 days whose parents decided to not start, or discontinued, breastfeeding. Infant formula with scGOS/lcFOS+50%FERM, scGOS/lcFOS+15%FERM, 50%FERM and scGOS/lcFOS were tested. Parents completed standardised seven-day diaries on GI symptoms, crying, sleeping and stool characteristics each month until the infants were 17 weeks. Results: All the formulas were well tolerated. At four weeks, the overall incidence of infantile colic was significantly lower (8%) with scGOS/lcFOS+50%FERM than scGOS/lcFOS (20%, p = 0.034) or 50% FERM (20%, p = 0.036). Longitudinal modelling showed that scGOS/lcFOS+ 50%FERM-fed infants also displayed a persistently lower daily crying duration and showed a consistent stool-softening effect than infants who received formula without scGOS/lcFOS. Conclusion: The combination of fermented formula with scGOS/lcFOS was well tolerated and showed a lower overall crying time, a lower incidence of infantile colic and a stool-softening effect in healthy term infants. These findings suggest for the first time that a specific infant formula has a preventive effect on infantile colic in formula-fed infants. | Keywords: | fermented formula; gastrointestinal tolerance; infant formula; infantile colic; prebiotic | Document URI: | http://hdl.handle.net/1942/26462 | ISSN: | 0803-5253 | e-ISSN: | 1651-2227 | DOI: | 10.1111/apa.13844 | ISI #: | 000405216700029 | Rights: | ©2017 The Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica 2017 106, pp. 1150–1158 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Vandenplas_et_al-2017-Acta_Paediatrica.pdf | Published version | 408.05 kB | Adobe PDF | View/Open |
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